ABSTRACT
This study included 50 male patients with type 2 diabetes aged 56.2 +/- 7.8 years, with a body mass index [BMI] of 28.3 +/- 2.6 kg/m 2, a duration of diabetes 10.6 +/- 6.4 years; in addition, 25 age- matched lean healthy subjects were taken as a control group. Body mass index [BMI], waist to hip ratio [WHR], plasma lipids, homeostasis model assessment of insulin resistance [HOMA-IR], plasminogen activator inhibitor-1 antigen [PAI-1 Ag] and plasma total testosterone [T] were assessed. Carotid intima-media thickness [IMT] and plaque score [PS] were evaluated by ultrasound. The study concluded that total serum testosterone is inversely associated with carotid atherosclerosis determined by ultrasonographically evaluated carotid IMT and PS in men with type 2 diabetes. Low serum testosterone is associated with an adverse cardiovascular risk profile in these patients