Functional Features of Hemocoagulation in rats with Experimentally formed Arterial Hypertension in Conditions of Increased Motor Activity

In rats with experimentally formed arterial hypertension, lipid perxidation in the plasma, amplification of blood chotting mechanisms with a decrease in anticoagulation and fibrinolysis was noted. Regular forced jogging provided the experimental rats with a positive dynamic of all the indicators considered. Thus, with increased muscular activity, the level of acyl hydro-peroxides of plasma decreased in rats with arterial hypertension formed due to the enhancement of its antioxidant activity. In addition, with the increase in muscle activity in experimental rats, normalization of clotting factor activity, indices of general coagulation tests, antithrobin III activity and protein C was achieved. This was accompanied by a normalization of the level of plasminogen, a2-antiplasmin and spontaneous euglobulin lysis time. In rats with formed arterial hipertension with stgandard physical activity, the initial violations of the measured parameters were completely preserved (AU)

Physiological Peculiarities of Hemocoagulation in Newborn Calves after Cresacin and Hamavit Application

Newborn calves are still often registered to have dyspepsia or acute hypoxia. These disturbances are very often accompanied by the development of hemostasiopathy. There are no definite approaches to its correction yet. Aim: To determine activity dynamics of coagulation hemostasis in newborn calves with dyspepsia or after acute hypoxia at birth against the background of cresacin and hamavit application. Materials and Methods: We examined 33 newborn calves after acute hypoxia at birth (experimental group №1) and 38 calves with noninfectious dyspepsia (experimental group №2). In the course of 5 days all the experimental calves were given cresacin 4mg/kg a day in the morning for drinking and were injected hamavit intramuscularly 0.03 mg/kg once a day in the morning. We applied biochemical, hemostatic and statistical methods of investigation. The control group in our research was composed of 35 healthy newborn calves. Results of Research: Both groups of experimental calves were noted to have similar level rise of plasma lipids’ peroxidation, strengthening of coagulation process, weakening of anticoagulation processes and fibrinolysis. Application of cresacin and hamavit combination to the examined animals provided similar positive dynamics of all the accountable indices in them. In the result of their application we noted some lowering of plasma acylhydroperoxides’ level (more than in 2.2 times) on behalf of the increase of its antioxidant activity (more than by 30.0%) till the level of the norm. The newborn calves with dyspepsia or after acute hypoxia turned out to be able to reach full activity normalization of all the initially activated coagulation factors against the background of the conducted correction. The time of registered coagulation tests in the observed newborn calves from both experimental groups reached the level of the control values against the background of the correction. In the result of the conducted correction the activity of antithrombin III and protein C in the observed calves from the experimental groups increased by more than 13.0% and by more than 15.0% what provided their normalization. It was accompanied by level rise of plasminogen what provided activity normalization of fibrinolysis system in all the experimental animals. Conclusion: Newborn calves with dyspepsia or after acute hypoxia at birth are characterized by coagulation activity and weakening of plasma anticoagulant and fibrinolytic mechanisms. The application of cresacin and hamavit combination to both categories of newborn calves provides normalization of plasma coagulation activity and mechanisms of its limitation.