ABSTRACT
Objective China has the biggest population of commonly encountered liver diseases , so hepatology resear-ches are of great importance to human health .In order to comprehensively collect/organize and effectively share/display liv-er physiopathology knowledge scattered around databases and literature , a Human Liver Disease Ontology ( HuLDO ) is built and applied in many ways .Methods HuLDO systematically classified and annotated various human liver diseases based on extensive cross mapping and integration of several authoritative nomenclatures of diseases and two monographs of hepatology .Results In the present version , HuLDO encompassed knowledge of 227 human liver diseases and was enriched by plenty of synonyms,definitions, descriptions, references, and logical or pathological relations between different disea-ses.Compared with other existing nomenclatures , HuLDO extended far beyond them in the scope of liver diseases .Several applications of HuLDO in database construction , knowledge collection and text mining were also described .Conclusion HuLDO offers a sound basis for knowledge mining , data integration and data analysis in the field of hepatology .HuLDO is publicly available at ftp://liveratlas.hupo.org.cn/5.liver 5.liver%20Disease%20Ontology/.
ABSTRACT
Objective To study effects of Shoucong capsule on the learning-memorial ability,CAT and MAO activities in brain tissue of AD rat.Methods Male Wistar rats were randomly divided into 5 group:blank compared group,model compared group,Naofukang group and Shoucong capsule(low,high dose) group,every group contained 9 rats.They were injected with D-galactose into the neck and injected with scopolamine into the intraperiton to making AD compound model rats.The learning-memorial ability were examined by diving-stand test,and CAT and MAO activities in brain tissue were determined by spectrophotometry.Results Shoucong capsule greatly deceased error time and enhanced the electric latent period,and enhanced the activities of CAT while deceased the activities of MAO in model rats.Conclusions Shoucong capsule has significantly effect of preventing and treating senile dementia in AD rats by enhancing the activities of CAT and deceasing the activities of MAO in brain tissue.
ABSTRACT
Objective To study the mechanism of Shoucong to prevent and cure Alzheimer's disease by observing the effect of shoucong capsule on total autioxidative capacity (TAOC), Lipofuscin (LIP) in AD rat brain tissue and blood, and brain tissue pathological changes. Methods Male wistar rats were randomly divided into 5 group:blank compared group, model compared group, Naofukang group, Shoucong Capsule (low, high dose) group. AD compound model rats were made by injected with D-galactose on the neck of rats, then injected with scopolamine in the intraperiton of rats. They were prevented and cured with Shoucong Capsule. TAOC, LIP level in rat brain tissue and blood were examined with spectroscopic analysis, brain tissue pathological changes were observed under light microscope. Results Compared with AD model group, Shoucong Capsule enhanced TAOC level in rat brain tissue and blood, deceased LIP level in rat brain tissue, and lessened the pathological injury of dementia rats. Conclusions Enhancing TAOC level and deceasing LIP level in brain tissue and blood may be one of the mechanism for Shoucong Capsule to prevent and cure Alzheimer's disease.