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Jishou University School of Medicine has actively explored the application and effect of online teaching of "ideological and political education" in nursing courses under the COVID-19 epidemic. Taking 135 undergraduates majoring in nursing in batch 2017 as research objects, this study introduces the implementation scheme of online teaching of "ideological and political education". The results show that the online teaching of "ideological and political education" can help nursing undergraduates to establish the professional identity and cultivate medical ethics during the epidemic, to enhance the awareness of the prevention and control of the epidemic, to strengthen the understanding of relevant nursing professional knowledge, and improve students' learning attitude, worthy of reference and promotion.
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Objective:To investigate the value of rate-pressure product (RPP) in predicating the prognosis of postural tachycardia syndrome (POTS) in children.Methods:Fifty-three children (26 males and 27 females) aged 5 to 15 who had syncope of unknown reasons or presyncope and were diagnosed with POTS by head-up tilt test (HUTT) at the Children′s Syncope Specialist Clinic, the Second Xiangya Hospital, Central South University from April 2012 to May 2019 were selected as the POTS group.Thirty-eight children aged 5 to 16 (19 males and 19 females) who underwent medical examinations at the Children′s Health Specialist Clinic of the Second Xiangya Hospital, Central South University over the same period were enrolled as controls (control group). POTS children were followed up after intervention and they were divided into the response group ( n=40) and the non-response group ( n=13) according to the follow-up results.The products (RPP0, RPP5, RPP10) of the heart rate (HR0, HR5, HR10) and systolic blood pressure (SBP0, SBP5, SBP10) at baseline (HUTT 0 min), HUTT 5 min and HUTT 10 min were calculated.Statistical analysis was performed using SPSS 22.0 software and EmpowerStats software. Results:(1) There was no statistical difference in age and gender between the POTS group and the control group (all P> 0.05). (2) HR5 [(115.45±14.50) times/min vs.(95.79±13.89) times/min], HR10 [(120.57±16.13) times/min vs.(96.05±12.43) times/min], RPP5 (12 814.55±2 304.56 vs.10 371.42±1 910.20), and RPP10 (13 449.17±2 360.40 vs.10 523.18±1 771.48) in the POTS group were significantly higher than those in the control group( t=0.799, 7.842, 5.747, 6.446, all P<0.01). No statistical difference of HR0 and RPP0 was observed between the 2 groups (all P>0.05). (3) In the POTS group: HR5 [(98.73±12.43) times/min vs.(113.77±17.65) times/min], HR10 [(96.90±13.96) times/min vs.(119.08±13.52) times/min], RPP5 (11 125.45±1 952.35 vs.12 914.69±3 192.12) and RPP10 (10 819.58± 2 144.26 vs.13 375.46±2 807.01) in the response group were significantly lower than those in the non-response group( t=3.406, 5.012, 2.432, 3.455, all P<0.01). HR0 and RPP0 were no significantly different between the 2 groups(all P>0.05). (4) When SBP10<114 mmHg(1 mmHg= 0.133 kPa), the probability of response after POTS intervention increased by 10% with every 1 mmHg increase in SBP10, and there was a non-linear relationship between the 2 group ( P<0.05). (5) The receiver operating characteristic curve suggested that when RPP5 was 11 548.50, the sensitivity and specificity to predict the response after POTS intervention were 81.82% and 61.70%, respectively.When RPP10 was 10 988.00, the sensitivity and specificity were 77.78% and 86.21%, respectively. Conclusions:RPP is closely related to the intervention effect of POTS in children.RPP5 and RPP10 can predict the prognosis of POTS in children.There is a non-linear relationship between SBP10 and the intervention effect of POTS in children.
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Jishou University promotes the education reform for postgraduate students majoring in clinical medicine with the guidance of "Serving the Local Demand for Professional and Improving the Training Quality of Professional":moral education first,strengthening the thought of serving people wholeheartedly and developing good style of study;focusing on the development of clinical skills and clinical research competency;scientifically setting up curriculums and actively carrying out teaching innovation on the basis of the plan;attaching importance to supervision by innovating guidance mode and perfecting quality supervision mechanism.It has achieved remarkable results and laid a solid foundation for the postgraduate education to achieve the "connotative development of meeting the service demand and improving the teaching quality".
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Objective To discuss the relationship between body mass index(BMI)and flag_raising syncope ( PS)and micturition syncope(MS)in children and adolescents. Methods One hundred and six children and adoles_cents with PS or MS diagnosed at the Department of Dediatric Cardiovasology,Childrenˊs Medical Center,the Second Xiangya Hospital,Central South University from January 2003 to September 2017 were studied,including 51 males and 55 females,and their ages ranged from 5 to 18 years. There were 63 cases in the PS group(21 males and 42 females) and 43 cases in the MS group(30 males and 13 females). One hundred healthy children and adolescents including 50 males and 50 females who had routine healthy examinations at the hospital in the same period were selected as control subjects(healthy control group). Body length and body mass were measured,and BMI was calculated. Statistical inves_tigations were conducted with SDSS 22. 0 software. Results (1)The body mass and BMI in the PS group were lower than those in the MS group[(36. 33 ± 9. 85)kg vs.(42. 85 ± 12. 44)kg;(16. 56 ± 2. 41)kg∕m2 vs.(18. 48 ± 3. 04) kg∕m2],and the differences were statistically significant(F﹦7. 529,12. 411,all P〈0. 05). There was no difference in body length among the PS group,the MS group and the healthy control group[(146. 62 ± 12. 89)cm vs.(150. 79 ± 12. 78)cm vs.( 149. 75 ± 16. 02 )cm,F ﹦1. 314,P 〉0. 05 ]. No differences were found in age,frequency,body length,body mass and BMI between the PS syncope group and the MS group with different genders(all P〉0. 05).(2) The number of BMI_underweight children increased in the PS group(82. 53%,52∕63 cases)compared with that of the MS group(58. 14%,25∕43 cases)and that of the healthy control group( 52. 00%,52∕100 cases),and the difference was statistically significant(χ2 ﹦14. 556,P〈0. 01).(3)The positive rate by head_up tilt test(HUTT)was 72. 64%(77∕104 cases),and HUTT of the PS group was higher than that of the MS group[82. 53%(52∕63 cases)vs. 58. 14%(25∕43 cases)],and there was a significant difference statistically(χ2 ﹦7. 656,P〈0. 01). Conclusions Low BMI is prone to PS in children and adolescents.
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Objective To construct the dynamic assessment system for practice base of professional master's degree in clinical medicine.Methods The teaching managers,clinical experts,postgraduate tutors and postgraduates of seven tertiary general hospitals with standardized training qualifications for residents in Hunan province were selected.Using the literature review and site investigation,we drafted the framework and score-factor of the dynamic assessment indicator system and adopted the percentage system to construct the assessment system.Results We interviewed and discussed with 28 teaching managers,21 clinical experts,35 graduate tutors and 112 graduate students; the response rate of all interviewees was 100％.The dynamic assessment system was composed of 4 first-level indicators and 20 second-level indicators; the score-factor of the primary indicator was 25％,and the score-factor of the secondary indicator was 5％.Conclusion The established dynamic assessment system has reasonable indicators and strong operability,and can provide useful reference.
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Objective@#To construct the dynamic assessment system for practice base of professional master's degree in clinical medicine.@*Methods@#The teaching managers, clinical experts, postgraduate tutors and postgraduates of seven tertiary general hospitals with standardized training qualifications for residents in Hunan province were selected. Using the literature review and site investigation, we drafted the framework and score-factor of the dynamic assessment indicator system and adopted the percentage system to construct the assessment system.@*Results@#We interviewed and discussed with 28 teaching managers, 21 clinical experts, 35 graduate tutors and 112 graduate students; the response rate of all interviewees was 100%. The dynamic assessment system was composed of 4 first-level indicators and 20 second-level indicators; the score-factor of the primary indicator was 25%, and the score-factor of the secondary indicator was 5%.@*Conclusion@#The established dynamic assessment system has reasonable indicators and strong operability, and can provide useful reference.
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Here, we aimed to study the effect of the forkhead box O1-insulin receptor substrate 2 (FOXO1-IRS2) gene interaction and the FOXO1 and IRS2 genes-environment interaction for the risk of type 2 diabetes mellitus (T2DM) in a Chinese Han population. We genotyped 7 polymorphism sites of FOXO1 gene and IRS2 gene in 780 unrelated Chinese Han people (474 cases of T2DM, 306 cases of healthy control). The risk of T2DM in individuals with AA genotype for rs7986407 and CC genotype for rs4581585 in FOXO1 gene was 2.092 and 2.57 times higher than that with GG genotype (odds ratio [OR] = 2.092; 95% confidence interval [CI] = 1.178–3.731; P = 0.011) and TT genotype (OR = 2.571; 95% CI = 1.404–4.695; P = 0.002), respectively. The risk of T2DM in individuals with GG genotype for Gly1057Asp in IRS2 gene was 1.42 times higher than that with AA genotype (OR = 1.422; 95% CI = 1.037–1.949; P = 0.029). The other 4 single nucleotide polymorphisms (SNPs) had no significant association with T2DM (P > 0.05). Multifactor dimensionality reduction (MDR) analysis showed that the interaction between SNPs rs7986407 and rs4325426 in FOXO1 gene and waist was the best model confirmed by interaction analysis, closely associating with T2DM. There was an increased risk for T2DM in the case of non-obesity with genotype combined AA/CC, AA/AC or AG/AA for rs7986407 and rs4325426, and obesity with genotype AA for rs7986407 or AA for rs4325426 (OR = 3.976; 95% CI = 1.156–13.675; P value from sign test [P(sign)] = 0.025; P value from permutation test [P(perm)] = 0.000–0.001). Together, this study indicates an association of FOXO1 and IRS2 gene polymorphisms with T2DM in Chinese Han population, supporting FOXO1-obesity interaction as a key factor for the risk of T2DM.
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Humans , Asian People , Diabetes Mellitus, Type 2 , Genotype , Multifactor Dimensionality Reduction , Obesity , Polymorphism, Single NucleotideABSTRACT
Based on the idea of science, feasibility, development and characteristics; and the poli-cies or regulations of our country, we try to discourse the dynamic assessment system of clinical medicine master degree tutors from the assessment aim, assessment objects, annual evaluation, assessment content, assessment indicators and scoring criteria, and the results of the assessment and treatment. We hope our works can provide some constructive insights for the construction and development of dynamic assessment system on tutors.
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Aim To investigate the effects of meloxi-cam on the proliferation,migration and expression of PTEN of human colorectal cancer LoVo cells.Meth-ods The colony formation test was used to detect the effect of meloxicam on the proliferation of LoVo cells. The cell migration assay was applied to analyze the effect of meloxicam on LoVo cells activity.The RT-PCR assay was used to detect the effect of meloxicam on the mRNA expression of PCNA and PTEN gene. The western blot assay was applied to analyze the effects of meloxicam on the expression of PTEN pro-tein.The recombinant adenovirus and Annexin-V assay were used to testify the relationship between PTEN gene and anti-cancer effect of meloxicam.Results Compared with the control group,meloxicam could in-hibit the colony formation and PCNA protein expression of LoVo cells.At 48 h and 80 μmol·L -1 ,the expres-sion of PCNA protein was reduced to 61 .57% ± 2.81 %(T =7.086,P =0.01 9),the mRNA expres-sion of PTEN gene increased to 1 60.43% ±4.71 %(T=24.244,P =0.002),and the expression of PTEN protein increased to 1 52.63% ±3.33%(T =27.359, P =0.001 ).Results Annexin-V test indicated that the anti-cancer effect of meloxicam was associated with the up-regulated expression of PTEN.Conclusions Meloxicam can inhibit the proliferation and migration of LoVo cells by up-regulating the expression of PTEN.
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Objective To compare and analyze of three therapeutic schemes for type 2 diabetes mellitus(T2DM ) using the cost-effectiveness .Methods Using the basic idea of pharmacoeconomics evaluate cost-effect analysis method for three therapeutic schemes(oral glucose-lowering drugs ,oral glucose-lowering drugs + insulin injection one time ,oral glucose-lowering drugs + insu-lin injection twice) .Results The three therapeutic schemes average cost of arrived to 827 .30 yuan/3 months ,1 714 .50 yuan/3 months and 1 087 .50 yuan/3 months ,respectively(P=0 .00);the efficiency of control fasting blood glucose were 56 .51% ,51 .69%and 57 .04% ,respectively (P=0 .754);the efficiency of control 2 h postprandial blood glucose were 50 .56% ,40 .68% and 55 .63% , respectively (P=0 .097);the cost-effectiveness ratio of fasting blood glucose were 14 .64 ,33 .17 and 19 .06 ,respectively ;the cost-ef-fectiveness ratio of 2 h postprandial blood sugar were 16 .36 ,42 .15 and 19 .55 ,respectively .For the oral glucose-lowering drugs group as reference ,the cost-effective ratioscost of control fasting blood glucose and control 2 h postprandial blood glucose were -184 .4 and -89 .8 for oral glucose-lowering drugs + insulin injection one time ,respectively ;the cost-effective ratioscost of control fasting blood glucose and control 2 h postprandial blood glucose were 484 .8 and 51 .26 for oral glucose-lowering drugs + insulin in-jection twice ,respectively .Conclusion According to the principles of economics ,oral medication has the highest cost-effectiveness ratio in the treatment for T 2DM ,and oral medication + insulin injection twice has better therapeutic efficacy .
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Using content analysis method based on word frequency analysis,this paper defines and analyzes the status and development of Information Ethics research in China,and pays attention to the effects of information ethics on the clinical pharmacy.
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Recently, Clinical pharmacy becomes a new specialty of higher education in China. Therefore, building clinical pharmacy teaching quality monitoring system (CPTQMS) is very important not only for improving the teaching quality but also for training inter-disciplinary talents. We try to discuss the connotation and practice of CPTQMS from the objectives, measures and information system. We hope our work can present valuable suggestions for the construction and improvement of CPTQMS in Chinese higher education.
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Bioinformatics is a new field of biomedical science which based on biological,information technology to storage,retrieval and analysis the biological data.This emerging subject is important for the improvements of scientific ideas and ability of biomedical graduate students.Based on the medical background and future study of the graduate students,it is a key point that how to performing the teaching work in accordance with the student's aptitude.To promote the level of bioinformatics course and enrich the theory knowledge and ability of practice of the medical graduate students,we discuss three relate issues such as the content of courses,teaching term and teaching model in this paper.
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OBJECTIVE：To study the anti-asthmatic effects of artesunate on the durg-induced asthmat.METHOD:Drug-induced asthmatic model of guinea-pig. RESULTS:Using nubilous inhalation or intragastric administration,artesunate significantly inhibited the guinea-pig model asthma in a dose-dependent manner.It's ED50 were (99.95±7.69)mg.L-1(n=4) and (15.64±1.25)mg.kg-1.d-1(n=4) respectively. CONCLUSION:artesunate showed anti-athmatic effect in guinea-pig asthmatic model.