ABSTRACT
Objetivos. Aunque clásicamente se consideraba que era poco frecuente, en los últimos años se ha observado que existe una mayor frecuencia de onicomicosis en pacientes con lesiones psoriásicas de las uñas. El objetivo de este estudio ha sido valorar si entre los pacientes que consultan por onicomicosis existe una proporción de pacientes con psoriasis mayor de la esperada y si existen diferencias en la forma clínica de presentación de la onicomicosis. Diseño. Estudio post hoc a partir de dos registros epidemiológicos sobre pacientes diagnosticados clínicamente de onicomicosis. Emplazamiento. Asistencia Primaria (AP) y servicios de dermatología (DER) durante el año 2004 en Barcelona. Participantes. Las muestras recogidas fueron de n =1.051 y n = 1.906, respectivamente. Mediciones principales. Las características clínicas estudiadas fueron: localización, número de uñas afectadas, afectación de la matriz, tipo de onicomicosis, asociación con otras micosis y tratamiento prescrito. Resultados. En ambas muestras la proporción de pacientes psoriásicos (AP: 7,6 por ciento y DER: 3,7 por ciento) fue significativamente superior a la esperada (p < 0,001). En comparación con el resto, los pacientes psoriásicos presentaron mayor proporción de infecciones con afectación de la matriz (p < 0,05), mayor número de uñas afectadas (p < 0,05) y mayor tendencia a la localización simultánea en manos y pies. Conclusiones. A pesar de sus limitaciones, puesto que el diagnóstico de onicomicosis ha sido clínico y no por cultivo, los resultados de nuestro estudio aportan otro argumento a favor de la mayor frecuencia de onicomicosis en pacientes con psoriasis. Asimismo, los datos sugieren que en los pacientes psoriásicos la onicomicosis tiende a ser más severa.
Objective. Though classically considered rare, in recent years onychomycosis has been found to be more frequent in patients with nail psoriasis. This study aimed to assess whether patients consulting for onychomycosis present above average rates of psoriasis, and whether there are differences in the clinical presentation of onychomycosis in these patients. Design. This post hoc study was based on two epidemiological registers of patients with clinical diagnoses of onychomycosis. Setting. Primary care and dermatology units in 2004 in Barcelona. The primary care sample were 1,051 patients, and the dermatology sample, 1,906. Clinical features studied were: localization, number of nails affected, matrix involvement, type of onychomycosis, association with other types of mycosis, and treatment prescribed. Results. In both samples the proportion of patients with psoriasis (primary care: 7.6 percent and dermatology unit: 3.7 percent) were significantly above average (p < 0.001). Compared with the rest of the patients, patients with psoriasis presented a higher proportion of infection with matrix involvement (p < 0.05), a higher number of nails affected (p < 0.05) and a greater tendency towards simultaneous localization in fingers and toes. Conclusions. The diagnosis of onychomycosis was obtained clinically and not by means of culture. In spite of this limitation, the results of the study corroborate the knowledge that onychomycosis is more frequent in patients with psoriasis. The data also suggest that in patients with psoriasis the onychomycosis tends to be more severe.
Subject(s)
Humans , Male , Female , Middle Aged , Onychomycosis/epidemiology , Primary Health Care , Psoriasis/epidemiology , Comorbidity , Spain/epidemiology , PrevalenceABSTRACT
A four year study was conducted on a natural population of immature stages of Aedes aegypti after the re-invasion of Argentina by this vector in 1987. Thirty six plastic containers with 700 ml of dechlorinated water were placed in the La Plata Zoological Garden, La Plata, Argentina. A strip of filter paper around each container was added to facilitate egg counting. Eggs, larvae and pupae were counted weekly in each container from September, 1996 to August, 2000. After egg counting, papers were submerged to facilitate egg hatching and a new paper was placed in each container. Presence of A. aegypti immature stages was recorded from December-January to June during each of the four years of this study. In 1997, 13,105 eggs, 7,978 larvae and 1,476 pupae were registered with 54.7 % positive containers; during 1998, 8,194 eggs, 668 larvae and 142 pupae were recorded with 28.3 % positive containers; 13,510 eggs, 3,690 larvae and 743 pupae were registered during 1999 with 56.7 % positive containers; and 16,327 eggs, 4,669 larvae and 715 pupae during 2000 with 59.3 % of containers with presence of A. aegypti. Egg number and hatching rate were drastically reduced in 1998 when temperatures from December to May were 1 to 2.5 degrees C lower than the other years of this study. These colder than usual temperatures in the summer of 1998 were a consequence of the El Niño event.
Subject(s)
Male , Female , Animals , Aedes/growth & development , Insect Vectors/physiology , Argentina , Aedes/anatomy & histology , Aedes/physiology , Insect Vectors/growth & development , Longitudinal Studies , Oviposition , Population Density , Population Dynamics , SeasonsABSTRACT
Se estudió la presencia de IgE específica para proteínas del látex en el suero de 27 pacientes con mielomeningocele. La IgE se determinó por RAST y ELISA y su reactividad se analizó por inmunoblottig frente a un extracto proteico de látex natural amoniacado. Se detectaron 8 sueros con IgE específica para látex por todos los métodos ensayados. Todos ellos mostraron IgE elevada y revelaron una proteína de 14 kD. Estos resultados indican una incidencia del 29 por ciento de hipersensibilidad en este grupo, la que es comparable con la informada internacionalmente