Vitamin D Binding Protein as screening biomarker candidate for late-onset preeclampsia without intrauterine growth restriction during 16 week of gestation

The aim of this investigation was conducted to proteomic analysis of plasma obtained from pregnant women who destined to develop late-onset preeclampsia without intrauterine growth restriction [IUGR] during 16[th] week of gestation. Plasma was obtained from primiparous women during 16[th] week of gestation. 2-DE proteomic analysis was done for plasma from 11 healthy pregnant women and 11 women who developed preeclampsia later. Using bioinformatic analysis with Progenesis SameSpots ver4.0 software and ANOVA test, expression of 2 spots were statistically different between two groups. In preeclamptic state, expression of both were decreased, one of these spots was vitamin D binding protein [p-value: 0.047], the other one will be discussed in another paper. According to results, we concluded that during 16[th] week of gestation, occurance of late-onset preeclampsia without IUGR is predictable. During this week, pathology of disease is present and may be the process of placental degeneration and impaired placentation are include in disease pathology

study of "dihydropyrimidinase related proteins [DRPs]" expression changes influence in malignant astrocytoma brain tumor

Dihydropyrimidinase Related Proteins [DRPs] have known homologous to the Collapsing Response Mediator Proteins [CRMPs]. The DRP gene family has comprised four members, DRP 1, 2, 3, and 4, all out of which have considered to be involved in axonal outgrowth and path-finding. The protein has extracted from tumor, normal brain tissues, and then the protein purity has evaluated by Bradford test and spectrophotometric methods. In this study, proteins has separated by Two-Dimensional Gel [2DG] electrophoresis method and then spots have analyzed and compared using statistical data and specific software [Progenesis Same Spots].Spots have identified by pH isoelectric, molecular weights and data banks. The 2D gel has shown 800 spots totally. Two spots have reported for DRP2, and one spot has reported for DRP3 in the human brain proteome, that have differed in pH isoelectric, and Molecular Weights values. This protein family has involved in neuronal differentiation and axonal guidance, and abundantly influenced in the developing brain, but their expression persisted into adulthood. DRP2 has regulated by phosphorylation, Glycogen synthase kinase 3, regulate phosphorylation of DRP2 an inactive from, and induced neuronal polarity

Breast cancer: genetics, risk factors, molecular pathology and treatment

Breast cancer within incident of one million new cases each year has become one of the most common malignancies and leading cause of death among females. This disease is comprised of about 18% of women cancers. The availability of early detection and improved treatments may decrease the mortality rates which reflected in the United States and many other western countries. Breast cancer in over the past 20 years may also have contributed to the Increasing age, nulliparity, positive family history of breast cancer, and use of menopausal hormone therapy were positively risk factors associated with breast cancer. Therefore, studying this malignity is prominent due to its mortality world wild. Evaluation and study of different aspects of breast cancer have been established during past decays which, in this review, it is presented and discussed

study on the application rate of CSF test [cerebro spinal fluid] in diagnosing accute bacterial meningitis in infants and children under 5 years old in Tajrish shohada and Tehran mofid hospitals during 2005

Studying CSF [cerebro spinal fluid] is a simple and fast measure for diagnosing meningitis in children. For this reason, LP [umbar puncture] is used to treat csf. Regarding the side effects of LP, we decided to determine the positive points observed in the patients' files than total patients confined to bed in our selected population. In this study conducted by descriptive retrospective method, the records of 1705 infants and children suspected to meningitis, confined in Tajrish Shohada and Tehran Mofid Hospitals for LP test, were investigated. Data collected from these cases were statistically analyzed. Studies indicated that in 93.7% of infants and children tested by LP as well as csf tested, the results were negative, therefore due to the fact that LP is considered as a risky method for children, performing a test doesn't seem necessary in most cases. Results of this study also indicated that maximum rate of infection was among males and occurred in autumn.