ABSTRACT
Apresenta-se o relato de experiência da integração entre serviços de saúde públicos e privados, gestores e universidade, para a vigilância e controle da epidemia de COVID-19 em Tubarão, SC, Brasil. A cidade, universitária, cenário de grande fluxo de pessoas de diferentes locais do país, foi um dos primeiros municípios do estado catarinense com transmissão comunitária do SARS-CoV-2. São detalhadas as medidas adotadas com a criação do Comitê de Monitoramento da COVID-19, do Centro de Operações de Emergências Municipais em Saúde, e do Plano de Contingência da Doença. Passados 100 dias de pandemia, foram 5.979 casos notificados e 431 (7,2%) confirmados, dos quais 5 (1,2%) foram a óbito. Decisões precoces - suspensão imediata das atividades de comércio e eventos com aglomeração - podem ter limitado a propagação do vírus. As parcerias estabelecidas trazem inovação e subsidiam a gestão pública nas tomadas de decisão pautadas em evidências científicas.
Se presenta la experiencia de la integración entre los servicios de Salud Pública y privados, los administradores y la universidad para la vigilancia y el control de la epidemia de COVID-19 en Tubarão, Santa Catarina, Brasil. La ciudad universitaria, con un gran flujo de personas de diferentes partes del país, fue uno de los primeros municipios del estado con transmisión comunitaria de SARS-CoV-2. Las medidas adoptadas se detallan con la creación del Comité de Monitoreo COVID-19, el Centro de Operaciones Municipales de Emergencia en Salud y un Plan de Contingencia de la Enfermedad. Después de 100 días de pandemia, se reportaron 5,979 casos, 431 (7,2%) confirmados, de los cuales cinco (1,2%) murieron. Las decisiones precoces, la suspensión inmediata de las actividades comerciales y de los eventos con aglomeración han reducido la propagación del virus. Las asociaciones establecidas aportan innovación y subsidian la gestión pública en la toma de decisiones basadas en evidencia científica.
This article presents an experience report about integration between public and private health services, health service managers and the academy, for surveillance and control of the COVID-19 epidemic, in the municipality of Tubarão, Santa Catarina, Brazil. The city is home to a university and has a large flow of people from different parts of the country, as well as being one of the first municipalities in the state of Santa Catarina to report cases of community transmission of SARS-CoV-2. The measures adopted included the implementation of the COVID-19 Monitoring Committee, the Municipal Health Emergency Operations Center, and the COVID-19 Contingency Plan. After 100 days of pandemic, 5,979 cases had been reported, 431 (7.2%) had been confirmed, of which five (1.2%) died. Early decisions, such as the immediate suspension of business activities and crowded events, may have reduced the spread of the virus. The partnerships put into place have provided innovation and supported public service management in decision-making based upon scientific evidence.
Subject(s)
Humans , Coronavirus Infections/prevention & control , Coronavirus Infections/transmission , Coronavirus Infections/epidemiology , Public-Private Sector Partnerships/organization & administration , Health Plan Implementation , Interinstitutional Relations , Brazil/epidemiology , Advisory Committees , Pandemics , Public Health Surveillance , Epidemiological MonitoringABSTRACT
Abstract: New Delhi metallo-beta-lactamase-1 (NDM-1) is a bacterial enzyme that renders the bacteria resistant to a variety of beta-lactam antibiotics. A 20-year-old man was hospitalized several times for surgical treatment and complications caused by a right-sided vestibular schwannoma. Although the patient acquired several multidrug-resistant infections, this study focuses on the NDM-1-producing Acinetobacter spp. infection. As it was resistant to all antimicrobials tested, the medical team developed a 20-day regimen of 750mg/day metronidazole, 2,000,000IU/day polymyxin B, and 100mg/day tigecycline. The treatment was effective, and the patient recovered and was discharged from the hospital.
Subject(s)
Humans , Male , Young Adult , Acinetobacter/enzymology , beta-Lactamases , Acinetobacter Infections/microbiology , Cross Infection/microbiology , Drug Resistance, Multiple, Bacterial , Anti-Bacterial Agents/therapeutic use , Acinetobacter/drug effects , Acinetobacter Infections/drug therapy , Microbial Sensitivity Tests , Cross Infection/drug therapy , Treatment Outcome , Anti-Bacterial Agents/pharmacologyABSTRACT
A hanseníase é uma doença infecto-contagiosa crônica de caráter endêmico, causada pelo Mycobacterium leprae, cuja predileção pela pele e nervos periféricos lhe confere características peculiares. O objetivo deste estudo foi traçar o perfil clínico-epidemiológico dos pacientes portadores de hanseníase na região do Sul do Estado de Santa Catarina, no período de 01 de janeiro de 1999 a 31 de dezembro de 2003. Trata-se de pesquisa descritiva, do tipo série de casos, retrospectiva. A população estudada foi composta dos casos de hanseníase notificados ao Ministério da Saúde (Brasil) e os dados foram obtidos da Ficha de Notificação/Investigação de Hanseníase, coletados através de questionário. Entre os 57 casos estudados, observou-se a predominância do sexo masculino, cor branca e faixa etária de 40 a 59 anos. A maioria dos pacientes era multibacilar, pertencente às formas clínicas dimorfa ou virchowiana. O principal modo de detecção de casos novos foi demanda espontânea. A hanseníase apresentou coeficiente de detecção e taxa de prevalência baixos na região estudada, embora a distribuição dos casos não seja uniforme. A detecção ocorre por procura espontânea dos serviços de referência e o tratamento ainda é centralizado. Ações junto aos serviços de saúde podem facilitar a detecção precoce dos casos...
Subject(s)
Humans , Male , Female , Adult , Middle Aged , Aged, 80 and over , Health Profile , Leprosy/classification , Leprosy/prevention & control , Mycobacterium leprae , Surveys and QuestionnairesABSTRACT
Studies have demonstrated that HIV infection negatively affects the immune response to hepatitis B vacine. The present study evaluated the seroconversions to the recombinant vaccine against hepatitis B applied in HIV patients. Twenty-two patients were included in the study group all with confirmed HIV infection and with negative serum markers to hepatitis B. The control group was composed of 18 healthy individuals with negative markers for hepatitis B. All subjects were vaccinated with 20µg of ENGERIX B at 0,1 and 6 months (3 doses). The antibody response was quantitatively assessed 1 month after the third dose of recombinant vaccine. CD4 T lymphocyte counts were also performed in those beginning vaccination. Of 22 patients in the study group, only 10 (45.5 percent) responded to vaccination with protective levels (over 10 µlU/ml). In the control group, all of the subjects responded (p=0.005). Seventeen patients in the study group had their CD4 lymphocytes measured. The results suggested a direct relationship between the level of CD4 lymphocyte counts and response to the vaccine. The rate of response to hepatite B recombinant vaccine with 3 doses of 20µg of HBsAg in patients infected by the human immunodeficiency virus was significantly lower than in the control group. Patients with low CD4 T lymphocyte counts are likely to have an inadequate response to the current method of hepatitis B vaccination.