1.
Southeast Asian J Trop Med Public Health
;
1984 Dec; 15(4): 531-5
Article
in English
| IMSEAR
| ID: sea-31884
ABSTRACT
The efficacy of mefloquine against Plasmodium falciparum in continuous culture was studied. The development of mefloquine resistance in P. falciparum was significantly inhibited by a combination of mefloquine, pyrimethamine and sulfadoxine. By contrast, more resistant variants were selected in continuous culture without drug pressure or with pyrimethamine-sulfadoxine pressure. The most mefloquine resistant variants were selected by step-wise increases in mefloquine pressure.