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Arq. bras. oftalmol ; 83(2): 160-167, Mar.-Apr. 2020. tab, graf
Article in English | LILACS | ID: biblio-1088965

ABSTRACT

ABSTRACT Degenerative retinal diseases such as retinitis pigmentosa, Stargardt's macular dystrophy, and age-related macular degeneration are characterized by irreversible loss of vision due to direct or indirect photoreceptor damage. No effective treatments exist, but stem cell studies have shown promising results. Our aim with this review was to describe the types of stem cells that are under study, their effects, and the main clinical trials involving them.


RESUMO As doenças degenerativas da retina, como retinose pigmentar, distrofia macular de Stargardt e degeneração macular relaciona à idade, são caracterizadas por perda irre versível da visão devido a danos diretos ou indiretos aos fotorreceptores. Não existem tratamentos eficazes, porém os estudos com células-tronco mostraram resultados promissores. Nosso objetivo com esta revisão foi descrever os tipos de células-tronco em estudo, seus efeitos e os principais ensaios clínicos que as envolvem.


Subject(s)
Humans , Retinal Degeneration/therapy , Pluripotent Stem Cells/transplantation , Stem Cell Transplantation/methods , Retina/cytology , Clinical Trials as Topic , Treatment Outcome
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