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In recent years, the ancient Yin-Yang theory has been gradually adopted by modern researchers, especially European and American scholars, and it has also been applied to modern scientific research on sleep, viruses, metabolism, cancer, genes, autoimmune diseases, and so on. It is very promising and fruitful results have been reported. However, the understanding of the connotations of Yin-Yang theory is not sufficient and thorough enough in these studies. If we understand and apply Yin-Yang theory more comprehensively, it may provide us with additional potential mechanisms and research directions worthy of study. On the basis of promoting a comprehensive understanding of all three connotations of Yin-Yang theory, this review attempts to illustrate this theory, summarize its applications in modern scientific research, and reveal the potential research direction of modern medicine.
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With the aging of the population, the incidence of cerebrovascular diseases has increased significantly. In Western medicine, statins, aspirin and antihypertensive drugs are often used to treat mild and moderate cerebrovascular stenosis. For severe cerebrovascular stenosis, interventional technique and drug therapy are often used. In the course of treatment, it is not rare to see the side effects such as hypersensitivity of western medicine and damage of liver function, and it is not rare to see the patients with poor effect of drug therapy alone or short-term restenosis after intravascular stent implantation. Professor Gao Li, in Department of Neurology, Xuanwu Hospital of Capital Medical University, combined the modern medical theory of cerebral vascular stenosis with the theory of traditional Chinese medicine. According to the clinical manifestations, imaging and ultrasonic examination results of patients, cerebral vascular stenosis was divided into three syndrome types, such as phlegm obstruction and blood stasis type (mainly thickening of inner and middle membrane), qi stagnation and fire melting type (mainly plaque) and mixed type (both membrane thickening and plaque). The methods of invigorating spleen and removing dampness, clearing phlegm and removing blood stasis, soothing liver and relieving depression, clearing away heat and resolving phlegm, cooling blood and activating blood circulation, and the combination of two prescriptions were used for treatment of cerebral vascular stenosis, respectively. Meanwhile, the related Western medicine was added at the same time, which achieved better effect.
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Objective: To optimize the extraction technology of Shen Qi Jie Yu prescription. Methods: High performance liquid chromatography (HPLC) method was selected to determine the content of hesperidin of Shen Qi Jie Yu prescription of traditional Tang and granules. Decoction time, times and add water were used as the examining factors. L9 (34) orthogonal test was used as the best condition of extraction. Results: The hesperidin content in traditional Tang of Shen Qi Jie Yu prescription was significantly higher than granules. The order of the effect of hesperidin content is decoction time＞ decoction times＞add water. There is a significant difference in the number of boiling times. The best decoction condition of Shen Qi Jie Yu Prescription was 3 times for decoction, with 0.5 hours of decoction and 7 times of water addition. Conclusion: The high performance liquid chromatography of Shen Qi Jie Yu Prescription is the quantitative method and the preferred decoction technique of Shen Qi Jie Yu prescription is stable and reliable.
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The sub-health status is closely related to the functions and activities of heart in traditional Chinese medicine (TCM). The sub-health is commonly presented with a series of heart system symptoms such as palpitation, chest distress, shortness of breath, fatigue, fidgets and insomnia. It may also be accompanied with arrhythmia or blood pressure value between normal and high level. This heart system sub-health status can be transformed into re-lated heart system diseases with high possibility. This article made a review from aspects of theoretical literature, an-imal experiment, curative effect observation and clinical evaluation on the research progress of heart system sub-health status.
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<p><b>OBJECTIVE</b>To investigate the effect of 5-fluorouracil (5-FU) on the expression of ATP-binding cassette superfamily G member 2 (ABCG2) in human colon cancer cell SW480.</p><p><b>METHODS</b>SW480 cells were treated with various concentrations of 5-FU. CCK8 assay was utilized to detect the 5-FU IC50 to SW480 cells. Positive expression of ABCG2 was detected by flow cytometry, and mRNA expression of ABCG2 was detected by real time polymerase chain reaction (RT-PCR).</p><p><b>RESULTS</b>The 5-FU IC50 to SW480 cells increased as the drug concentration increased (P<0.05). Flow cytometry revealed that positive expression rate of ABCG2 in normal SW480 cells (group A) was (6.26±0.86)%. Immediately after treatment with 5-FU for 48 hours, the positive expression rate of ABCG2 (group B) was (3.43±1.18)% (P<0.05). In the second passage of cells after treatment with 5-FU for 48 hours, the positive expression rate of ABCG2 (group C) was (12.91±3.42)% (P<0.05). The mRNA expression of ABCG2 detected by RT-PCR was in accordance with the results from flow cytometry.</p><p><b>CONCLUSION</b>Expression of ABCG2 in SW480 cells can be affected by various concentrations of 5-FU.</p>
Subject(s)
Humans , ATP Binding Cassette Transporter, Subfamily G, Member 2 , ATP-Binding Cassette Transporters , Metabolism , Cell Line, Tumor , Colonic Neoplasms , Metabolism , Fluorouracil , Pharmacology , Neoplasm Proteins , MetabolismABSTRACT
To study the use of data mining techniques in analyzing the syndrome discipline of generalized anxiety disorder (GAD).
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<p><b>OBJECTIVE</b>To assess the advantage and disadvantage of laparoscopic abdomino-perineal resection and open abdominoperineal resection for low rectal cancer.</p><p><b>METHODS</b>Patients with low rectal cancer, collected from July 2003 to April 2006, were randomly divided into laparoscopic abdominoperineal resection group (37 cases) and open abdominoperineal resection group (37 cases). Operation time, number of lymph node removed, intra-operative blood loss, time to pass flatus, time to ambulate, time to discharge, complications, early recurrence, and economical cost were compared between the 2 groups.</p><p><b>RESULTS</b>All patients were performed successfully. For the first 10 patients, operation time of laparoscopic group was significantly longer than that of open group, but there was no significant difference between the 2 groups. Intra-operative blood loss of laparoscopic group was significantly less than that of open group, but it was reverse for the first 10 patients. There was no significant difference in time to pass flatus between the 2 groups. Time to ambulate in laparoscopic group was significantly earlier than that in open group. There was no significant difference in time to discharge between the 2 groups, but it was earlier for perineum closure in laparoscopic group. Relative complications of laparoscopic group, including pulmonary infection, abdominal wound infection or split, were significantly less than those of open group. There was no significant difference in number of lymph nodes removed, early recurrence between the 2 groups. Operation cost of laparoscopic group was significantly higher than that of open group, but there was no significant difference.</p><p><b>CONCLUSION</b>Advantages of laparoscopic abdominoperineal resection were characterized for not only minimal invasion and good cosmetic outcome but also less blood loss, complications, and earlier postoperative recovery. The operation time, total costs and oncological clearance of laparoscopic abdominoperineal resection patients were comparable with those of open procedure patients.</p>
Subject(s)
Aged , Female , Humans , Male , Middle Aged , Abdomen , General Surgery , Laparoscopy , Perineum , General Surgery , Rectal Neoplasms , Pathology , General Surgery , Rectum , Pathology , General Surgery , Treatment OutcomeABSTRACT
Primenopausal period syndrome is a kind of usual disease,and people's views differ in disease location,pathogenesis and treatment.We approach the disease from theory to expound that its disease location is Chong Channel and Ren Channel.We find that the imbalance of yin-yang,because of the deficiency in Chong Channnel and Ren Channel,is the source.We apply Chong Channel and Ren Channel,and we also harmonize yin-yang to cure the disease.