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To analyze the scope of prescription taste in the treatment of milk addiction in ancient and modern eras in order to provide a reference for selection of drugs in the treatment of milk addiction in future. The literatures on clinical prescriptions of ancient and modern medical experts for the treatment of mammitis and milk addiction were reviewed and selected, and the scope, sequence, similarity and difference between the ancient and modern medicines were analyzed by prescription metrology. Of totally 58 prescriptions for the treatment of milk addiction in ancient times, there were 27 prescriptions and 57 drugs were used for the treatment of milk addiction in the Song, Jin and Yuan Dynasties;in Ming and Qing Dynasties, 31 prescriptions, 59 drugs were applied. In the modern treatment of milk addiction, 44 clinical prescriptions and a total of 109 drugs were used. In Song, Jin and Yuan Dynasties saussurea, rhubarb, light powder, ginseng, croton, betel nut, fructus aurantii and cinnabarn were used commonly; in Ming and Qing Dynasties, rhubarb, saussurea, rhizome sparganii, semen pharbitidis, light powder and fructus aurantii were applied frequently; in modern times, bupleurum root, rhizome cyperi, angelica root and white peony root have been commonly used; there were similarities and differences in using medicine tastes among the 3 periods, the tastes in Song, Jin and Yuan Dynasties were more relatively approximate to those in Ming and Qing Dynasties, and the medicine similarity index between the 2 periods was large (S = 0.400), while the similarity index between the taste of modern medicine and that of the ancient was small (S = 0.088 and S = 0.094), showing more differences were present. There were 22 drugs were used both in ancient and modern eras; the number of drugs used in ancient time but not applied in modern time was 48; the number of drugs applied at present but not used in the ancient time was 85. The drugs with toxicity, very strong action, cathartic and cold characteristics used in ancient times are no longer applied in modern times, while those drugs with gentle action, warmth and promoting circulation, dissipating nodules mostly entering foot jue yin, shaoyang and foot yangming gastric meridians used in ancient times are still applied in modern times; at the same time, based on the ancient traditional Chinese medicine (TCM), many new drugs have been added in modern times, mainly those drugs with actions of promoting blood circulation and removing blood stasis, clearing and activating channels and collaterals, detoxification and resolving concretion, dissipating nodules and resolving phlegm, warming Yang and boosting kidney. Through comparative analysis of ancient and modern literatures and learning many medical experts' experiences in the treatment of milk addiction, an effective reference for the treatment of milk addiction can be provided, and the prescription metrology can also be used in other disease studies to approach TCM syndrome differentiation.
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Objective To establish the method for quality control of ethyl-acetate parts of Ferula sinkiangesis. Methods HPLC was used to detect the contents of ferulic acid, farnesiferol A and farnesiferol C. Waters XTerra RPC18 column (250 mm×4.6 mm, 5 μm) was used; acetonitrile-0.1% phosphoric acid was as mobile phase with gradient elution; flow rate was 1.0 mL/min; detective wavelength was 324 nm; temperature was 30℃; sample volume was 10 μL ResultsFerulic acid, farnesiferol A, and farnesiferol C showed a good linear relationship range from 0.05– 1.0 mg/mL, 0.132–2.64 mg/mL, and 0.118–2.36 mg/mL, respectively. The average recovery rates were 99.34%, 98.96% and 99.24% respectively. The contents of ferulic acid, farnesiferol A and farnesiferol C were 33.4, 76.5, 72.3 mg/g respectively.Conclusion The method was simple, accurate and repeatable, with good repeatability and stability, which can be used for the quality control of ethyl-acetate parts ofFerula sinkiangesis.
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Objective To establish a high-throughput detection of medicine on DPPH free radical scavenging activity;To analyze and preliminarily screen the anti-oxidant activity part of Ferula sinkiangensis. Methods Taking DPPH free radical scavenging rate of ascorbic acid as positive control, and IC50 as the evaluating criterion of DPPH free radical scavenging capability, oxidation resistance of different polar parts (petroleum ether part, ethyl acetate part, methyl alcohol part, and water part) of Ferula sinkiangensis was evaluated and screened. Results Different polarity parts of Ferula sinkiangensis DPPH radical scavenging of IC50 were:petroleum ether part 3252.22 μg/mL, ethyl acetate part 36.22 μg/mL, methyl alcohol part 32.22 μg/mL, water part 2643.38 μg/mL, and positive control group ascorbic acid 27.16 μg/mL. Conclusion The ethyl acetate and methyl alcohol parts of Ferula sinkiangensis were effective anti-oxidant activity site to eliminate DPPH free radicals. In this study, a simple, sensitive, and high-throughput detection method of DPPH radical scavenging assay was established to provide reference for the anti-oxidation medicine detection screening.
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This article was aimed to compare similarities and differences of medication rules of clinical prescriptions from nine doctors in order to analyze and discuss the clinical medication features of four doctors of the School of Integrative Medicine, who were Zhang Xichun, Tang Rongchuan, Y un Tieqiao, and Lu Y uanlei. The clinical medical records of Dr. Zhang Xichun and eight other doctors were selected in this study. The traditional literature metrology methods and formula metrology were used in the comparative analysis of indicators on four qi, five flavours, channel tropism, supplementation and drainage of commonly used herbal medicine. The results showed that the top five herbs used by doctors of the School of Integrative Medicine were prepared licorice, bighead atractylodes rhizome, Poria, Radix Paeoniae Alba, Angelica, which had the effect of nourishing qi and blood, supplementation and drainage at the same time. Most of the herbs were used to nourishing qi and yang. Dr. Y un Tieqiao preferred to nourish yin and blood. Medications used by doctors of the School of Integrative Medicine were mostly cold and cool in nature as well as acrid and sweet in flavour. Dr. Zhang Xichun had significant correlation with Dr. Tang Rongchuan and Dr. Lu Y uanlei of the School of Integrative Medicine. The correlation coefficients were 0.826 and 0.701, respectively (P <0.05). There were no significant correlation between Dr. Zhang Xichun and other doctors. The cluster analysis revealed that Dr. Zhang Xichun, Dr. Tang Rongchuan and Dr. Lu Y uanlei, who were of the School of Integrative Medicine, can be classified in one category. And Dr. Y un Tieqiao can be classified in a separate category. Doctors who were not of the School of Integrative Medicine were not in the same category. It was concluded that there were similarities in the medication rules of four doctors of the School of Integrative Medicine. However, they also had their own characteristics.
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Objective: To study the nature and flavour of LIU Wan-su’ drug application and the tendency of cold or warm in his prescription; analyze LIU Wan-su’s medical sect by the index of prescription metrology. Methods: Combining the traditional documents with prescription metrology, selecting three doctors before or after LIU Wan-su in Jin and Yuan Dynasty as comparison to expose the characteristic of prescription metrology in his prescription. Results: Wen tonic frequency of each prescription on average, LI Dong-yuan(1.10),ZHU Dan-xi(0.97), LIU Wan-su (0.77), ZHANG Zi-he(0.65); Han tonic frequency of each prescription, LI Dong-yuan (1.34),ZHANG Zi-he (1.00), LIU Wan-su (0.94), ZHU Dan-xi(0.80);Cool and warm drug ratio of four sects in Jin and Yuan Dyanstay, ZHU Dan-xi (0.97),LI Dong-yuan(0.83), LIU Wan-su (0.82), ZHNAG Zi-he (0.58).Cool and warm prescription ratio, ZHANG Zi-he(1.50), LIU Wan-su (0.87), LI Dong-yuan(0.76), ZHU Dan-xi (0.50).Conclusion: As the exponent of "theory of fi re and hot", it will be better to classify LIU Wan-su as " Hejian sect" since his drug application was not limited within cold and cool. To some extent, it is more important to judge a Chinese traditional doctor by syndrome identifi cation rather than only by his drug frequency.
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Objective:To understand the difference of prevalence rate and main symptoms of northwest dryness syndrome(NDS) of the long staying and temporary residents at Xinjiang by comparing the cotton workers in Shihezi come from mainland with inhabitant of Xinjiang,under the environment of NDS.Methods:To design questionnaire according to the Chinese medicine theories and modern epidemiology method,and carry out sampling questionnaire in cotton workers of Shihezi,Hetian,Urumqi,Yili and Leshan,then carry out syndrome differentiation with computation and statistical analysis about NDS.Results:The distributing date,syndromic types and main symptoms scores of NDS in the cotton workers in Shihezi and other areas were obtained from 3658 questionnaires.The highest attack rate of NDS on cotton workers was in Hetian.The attack rate in Sichuan was higher than that in Shizihe(P0.05).The higher scores,symptoms of DNS in Shizihe were the main symptoms of dryness syndrome,but the higher scores,symptoms of NDS in Hetian,Yili and Urumqi were the characteristic symptoms.The external-dryness score of cotton workers in Shihezi was obviously higher than that in other areas(P
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The medication characteristics of doctor ZHENG Chong-guang in Qing Dynasty was studied from prescription metrology range index,including properties,tastes,channel tropism and function index.It was found that his clinic prescription practice was different from other doctors in Jiangzhe province which originated from his territory character,the territory character of Xin'an school was disclosed,it was suggested that prescription metrology range index was an valuable impersonal index for doctor's territory character.
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Objective To investigate the prevalence and distribution of Yin and Yang deficiency syndrome on different nationalities in different parts of Xinjiang in order to offer epidemiology evidence for the research on the cause of dryness syndrome in northwest China.Methods The questionnaire was designed according to the Chinese medicine theories and the sampling questionnaire investigation in five regions including Hotan Xinjiang and Leshan Sichuan and Shanghai was carried out.Then a computation differentiation of Yin and Yang deficiency syndrome was done for the statistical analysis.Results Totally 5544 questionnaires were accomplished.In the five regions except Urumqi,the incidence of Yin and Yang deficiency syndrome in Xinjiang was higher than that of Shanghai and Sichuan(P
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Based on investigations on the manifestations occurred in oil workers working in the hinterland of desert areas, a new term, "desert dryness syndrome" (DDS) was introduced. An analysis were made on frequencies of symptom incidence, scoring, specific nature and affinity relationship the method of differential diagnosis for the severity, existing time of the illness and characteristics were introduced and performed quantitatively. Results showed that the DDS is an actual existing disorder. The incidence and structural types of oil - worker group was significantly different from those of non - oil worker group. It is claimed that DDS is different from conventional dryness syndrome and possesses physiological and pathological changes involving many organs and systems, which are closely connected with psychological and mental disturbances. Active measures should be taken for its prevention and treatment.