ABSTRACT
The purpose of this study is to compare the efficacy and safety of supra-cervical Foley Catheter and vaginal prostaglandin E[2] [PGE[2]] tablet and combination of supracervical Foley Catheter and PGE[2] tablet for cervical ripening and labor induction. 90 patients admitted for induction of labor with a Bishop score = 6 were randomized to receive a supracervical Foley catheter under traction [Foley group] or PGE[2] tablet vaginally [prostine group] or a combination of both [Foley + Prostine group]. Repeated insertion of prostine tablet after 8 hours was done if Bishop score was <7 in the last two groups. Oxytocin induction in the Foley group commenced once the catheter fell out spontaneously while in both the Prostine group and the Foley + Prostine group, after cervical ripening if regular uterine contractions were not achieved within 4 hours after the last PGE[2] tablet. No statistically significant differences were noted between groups in change in Bishop score, preinduction cervical ripening time and total induction time. Contractile abnormalities were more frequent in the Prostine group [20%] and the Foley + Prostine group [10%] than the Foley group [0%] [p=0.036]. There were no significant difference in mode of delivery or adverse neonatal outcomes. This study has shown that for preinduction cervical ripening, the Foley catheter is as effective as the PGE[2] tablet with added advantage of safety and more economic price, the addition of PGE[2] tablet to the Foley catheter did not provide additional efficacy, however better safety through decreased incidence of contractile abnormalities probably due to decreased dosage of prostine tablet
Subject(s)
Humans , Female , Labor, Induced , Prostaglandins E , Administration, Intravaginal , Combined Modality Therapy , Gestational AgeABSTRACT
This study was done at NEMROCK and other private as well as official governmental oncology centers, where 30 patients with residual or relapsed high grade gliomas received temozolomide at a dose of 200 mg/m2/day for five successive days to be recycled on day 21 for a total of six courses. Drug administration was quite safe with accepted toxicity profiles. The response parameters, including partial response, stationary disease and progressive neoplastic process, were documented in 33%, 45% and 22%, respectively
Subject(s)
Humans , Male , Female , Recurrence/adverse effects , Antineoplastic Agents, Alkylating , Glioblastoma , Astrocytoma , Tomography Scanners, X-Ray Computed , Treatment Outcome , Disease ManagementABSTRACT
Diabetics Mellitus complications approximalety 3-4 per 1000 pregnancies. It is a syndrome in which hereditasry and environmental factors intersect leading to inadequate insulin action. In this stud we assess fetal lung in family diabetic pregnant women through studding fetal lung circulation by means of pulmonary Doppler investigation, determining fetal lung volume and detection of other malformation if present by using 3D U/S. This study included 60 pregnant women [in the second half of pregnancy] who attended the high risk pregnancy clinic at El Galaa Teaching Hospital. They were classified into two group, group I [control] 20 cases and group II [test group] 40 cases subdivided group II A 20 cases with controlled diabetes and group II B 20 cases with uncontrolled diabetes. All were subjected to color Doppler investigation, 3D U/S and genetic pedigree analysis to select familiar diabetic and interpretation of the results as regards pulmonary circulation, lung volume, birth weight and outcome of pregnancy showed that Diabetes Mellitus wither controlled or not does not significantly alter the fetal pulmonary artery waveforms or fetal lung volume assessed by 3D U/S at does not affect either the fetal lung vasculature or fetal lung mass. However further studies are needed to assess the role of these recent diagnostic tools in evaluating fetal lung maturity