Comparative bioavailability of norfloxacin tablets based on blood and urine data

To assess the bioavailability of norfloxacin from urinary excretion relative to plasma concentration. Twelve healthy volunteers [22-33 years] participated in the study. Each received a previously developed [M], a local [L] and a multinational [Noroxin] tablet [Ref], 400 mg each, according to a random balanced three-way crossover design on 3 different days. Blood samples were collected over a 12-hour period and urine over a 24-hour period. Norfloxacin concentrations were analyzed by a validated HPLC method. An initial estimate of bioequivalence of the three products was obtained using analysis of variance on transformed data and based on confidence interval calculation. Elimination pharmacokinetic parameters [half-life and renal clearance] calculated from plasma concentration and urinary excretion data [mean values, n = 36] were comparable to reported values for norfloxacin. Interproduct differences in elimination parameters [mean values, n = 12] were statistically insignificant [F values, ANOVA]. Strong association was found between the mean of plasma concentration and urinary excretion rates for many volunteers [F values, regression analysis]. Relative bioavailability values calculated for the local and previously developed products relative to Noroxin were higher than 85% based on area under the curve and urinary excretion. Bioequivalence could not be established among the three tested products based on calculated 90% confidence intervals. Urinary excretion of norfloxacin may be a useful noninvasive tool for bioavailability assessment of norfloxacin oral formulations

Prevalence of amoebiasis and giardiasis infection in some closed communities in Tanta city, Gharbia governorate

Parasitic diseases continue to be a major medical problem in Egypt. The most important protozoal diseases are amoebiasis and giardiasis. In this work 20% of the residents of Police Central Security Forces Camp II [PCSF], Students Hostel and Geriatric Hostel were chosen randomly. Clinical examination and stool analysis were performed for the studied sample and all food handlers in these places. Showed higher prevalence of amoebiasis infection among studied sample compared to control group which was statistically significant [X[2]=17.374]. The highest prevalence rate was detected among residents of PCSF [51.8%]. Concerning giardiasis, the highest prevalence rate was recorded for residents of Geriatric Hostel [28.56%]. However, no statistically significant differences were found between the study sample and the control group. Recommendations were given, according to results obtained, to handle the problem of amoebiasis and giardiasis infection met with in closed communities

Serum procollagen III propeptide and plasma fibronectin in chronic hepatosplenic schistosomiasis

Hepalosplenic schislosomiasis is a chronic disease of the liver characterized by granulomalous reaction, portal fibrosis, and presinusoidal portal hypertension. This study was carried on twelve patients fulfilling pre-established clinical, biochemical and histologic criteria for the diagnosis of chronic hepatic schistosomiasis. The serum procollagen III propeptidc [PIIIP] level was significantly higher in those patients compared to the control individuals and insignificant increase in plasma fibrohectin level was noticed in chronic hepatic schistosomiasis