Molecular characterization of autosomal recessive non syndromic hearing loss in selected families from district Mardan, Pakistan

Deafness is the most common sensory disorder, which affects 1/1000 neonates globally. Genetic factors are major contributors for hearing impairment. This study was conducted to explore the linkage of DFNB loci and their mutations with NSHL in selected Pakistani families. We included 10 families with history of deafness from district Mardan, Pakistan. Blood sample [5ml] along with personal and clinical information was collected from the available family members including both diseased and un-affected individuals. Genomic DNA was amplified using loci specific STR markers to investigate the linkage of DFNB loci. Family found linked with DFNB4 locus was screened for SLC26A4 mutations. One out of the ten explored families was found linked with DFNB4 locus which was further investigated for SLC26A4 gene mutation through direct DNA sequencing. Two novel mutations were observed in the studied family, one at splice donor site [164+2T>G] and the other at position 164+5C>G only in the affected members of the linked family. DFNB4 locus was found linked in the present study which harbors SLC26A4 gene. The novel mutation of SLC26A4 gene at the splice donor site results in skipping of the first coding exon and thus can lead to loss of expression of SLC26A4 product in the inner ear

Congenital synechia and syngnathia: two case reports

This case report presents two cases of rare congenital malformation, i.e syngnathia. First case is of 2-day infant with bilateral fusion of maxilla and mandible, leaving a small anterior portion. After consultation with other concerned specialties, early intervention was planned and fusion was released to facilitate feeding. The infant suffered from frequent respiratory tract infections and subsequently died at the age of ten months. The second case is of 8-month baby girl with unilateral congenital maxillomandibular bony fusion without any other anomaly. She underwent general anesthesia for thorough examination and release of soft tissue union. Second surgery was performed after few months for removal of bony fusion. Good mouth opening was seen on 1 month follow-up

Partial nephrectomy in adults - a single-centre experience

Partial nephrectomy is the preferred procedure in benign renal lesions requiring surgical removal. It has also been accepted procedure for malignant renal conditions of smaller size. The aim of this observational study was to determine the outcome of partial nephrectomy in terms of complications and recurrence rates. Twenty patients with renal mass underwent this procedure from January 2010 till June 2014 at our Department, with mean age of 46.51 +/- 1.53 years. There were 14 males and 6 females. Renal mass on CT scan had the mean size of 3.80 +/- 1.15cm. The mean hospital stay in this series was 5.11 +/- 1.42 days, while mean operative time was 247 +/- 79.71 minutes. Twelve patients had malignant histology. They were followed using CT scan abdomen and pelvis with contrast at six and 12 months. Out of these, 10 [83.3%] patients were found to have no recurrence after six months

Treatment for symptomatic bacterial vaginosis: a randomized controlled trial

Objective: To compare the efficacy of multiple doses of vaginal clindamycin with a single oral dose of secnidazole for the treatment of bacterial vaginosis. Study Design: Double-blinded randomized controlled trial. Place and Duration of Study: Shifa Foundation Community Health Center, from March 2012 till February 2015

Methodology: After obtaining written informed consent, a pelvic examination was performed for the confirmation of symptoms of milky white vaginal discharge on speculum examination, positive Amine test and presence of clue cells on microscopy. Pregnant women, known diabetes or any immunocompromised condition, were excluded. Blinding of the patient, doctor, and the pharmacist was done. Study cohort was then divided into two groups, Group A received medicine pack A which contained active clindamycin and placebo oral preparation, whereas group B was given pack B which contained active 2-gm secnidazole with placebo vaginal cream. Primary outcome and therapeutic success were defined by correction of two out of three [normal Nugent score, negative Amine test, and no milky white discharge] on day 15

Results: At 15[th] day of treatment, 96.6% participants in vaginal clindamycin group [Group A], recovered from the bacterial vaginosis; whereas, [group B] 23% patients were cured in oral secnidazole group

Conclusion: Multiple doses of vaginal clindamycin are superior to single dose of oral secnidazole for the treatment of bacterial vaginosis

Comparison of renal function assessment by cystatin C and creatinine based equations for e-GFR in type 2 diabetics in different stages of albuminuria

Objective: To compare e-GFR estimated by creatinine or cystatin C based and combined creatinine and cystatin C based equations in type 2 diabetics in different stages of albuminuria. Study Design: Comparative cross-sectional study. Place and Duration of Study: Department of Chemical Pathology, Army Medical College Rawalpindi in collaboration with endocrinology outpatient department Military Hospital Rawalpindi, from Nov 2015 to Nov 2016

Material and Methods: A total of 119 type 2 diabetic subjects of either gender, aged 30- 60 years were enrolled in the study with duration of diabetes less than 15 years and were divided into further sub groups on the basis of degree of albuminuria determined by spot urine albumin to creatinine ratio [uACR]. Fifty age matched disease free controls with no history of any systemic disease were also included in the study. Known patients of type 1 diabetes, chronic inflammatory disorders, uncontrolled hypertension, thyroid disease, chronic kidney disease, on lipid lowering drugs, steroids, ACE inhibitors and pregnant ladies were excluded from the study. Serum creatinine serum cystatin C were assessed on fully automated chemistry analyzer selectra. E-GFR was calculated by online GFR calculator by National Kidney Foundation. Comparison of means of e-GFR calculated by various equations was carried out by one way ANOVA and post-hoc Tukey tests. Degree of agreement between various equations for the estimation of GFR was assessed by kappa statistics. A p-value less than 0.05 were considered statistically significant

Results: Mean e-GFR [ml/min/1.73m[2]] was lowest in cystatin C based CKD-EPI equation [89.56 +/- 39.84] followed by combined cystatin C and creatinine based CKD-EPI [92.34 +/- 37.88]. Values of e-GFR by creatinine based CKD-EPI equation [95.84 +/- 27.24], and by creatinine based MDRD equation [105.37 +/- 64.98] were both higher. In creatinine based MDRD, equation normo albuminuria and micro albuminuria groups did not show statistically significant difference as compared to each other and control group. The mean value of e-GFR was found to be lowest in the normo albuminuric diabetics when estimated by cystatin C based CKD-EPI equation [88.82 +/- 46.98] followed by combined creatinine and cystatin C based CKD-EPI equation [95.73 +/- 42.96]

Conclusion: Cystatin C based CKD-EPI equation for e-GFR identifies more patients with glomerular dysfunction in normo-albuminuric stage of DKD as compared to cystatin C and creatinine based CKD-EPI and creatinine based MDRD equations. Therefore, e-GFR estimated by serum cystatin C based CKD-EPI formula is a better option for assessing the renal status in patients of early DKD

Therapeutic evaluation of unani pharmacopoeial formulations for hisat-e-kulyah [nephrolithiasis]

Nephrolithiasis is one of the most common health hazards worldwide. Despite advance technology of lithotripsy the management of renal calculi remains a challenge. Most of the Indian patients prefer alternative medicine rather undergoing painful surgery. The present paper deals with case study in which a 33 years old male patient of bilateral multiple renal calculi was treated with Unani pharmacopoeia! medicine: Qurs Kaknaj, Qurs Kushta Hajnd Yahood, Arq Kasni and Sharbat-e-Buzoori Motadil as oral medication. Patient showed promising result in subsequent investigations and finally recovered from renal calculi without undergoing surgery?

Frequency and antimicrobial susceptibility pattern of methicillin resistant staphylococcus aureus in open fractures

Objective: to determine the frequency and antibiotic sensitivity of methicillin resistant staphylococcus aureus [MRSA] in open fractures

Study design: descriptive case series

Place and Duration of study: Orthopaedics and Traumatology Unit A Lady Reading Hospital Peshawar, from January 2014 to June 2016

Methodology: patients of both gender and all ages fulfilling the inclusion criteria were included in this study. Swabs were taken from wounds with Levine's technique and sent to the hospital laboratory immediately where standard methodology was adopted for culture and sensitivity of the pathogens in all cases and results were reported as per Clinical and Laboratory Standards Institute [CLSI] guidelines. All MRSA positive cases were isolated within 24 hours and the standard MRSA protocol implemented immediately

Result: a total of 200 open fractures were sampled over a period of two and a half years. Positive cultures of MRSA were obtained in 47[23.5%] patients. The mean age of the patient was 24 year [range 18 year to 52 year]. Males were 43[81.4%] while females 4[8.5%] in number. Open tibial fractures were highest [n=21, 44.6%] in number followed by femur [n=12, 25.5%]. Majority [n=15, 31%] of the fractures were Type IIIA. All of the isolated MRSA cultures were 100% sensitive to vancomycin, linezolid, teicoplanin, chloramphenicol and tigecycline while resistance was observed for ciprofloxacin, levofloxacin, clarithromycin, and erythromycin

Conclusion: methicillin resistant staphylococcus aureus infection in open fracture wound is not uncommon. The isolated pathogen showed a variable pattern of sensitivity and resistance to the antibiotics tested

Prevalence and morphology of internal Jugular Venous valves

Background: Catheterization of the internal jugular vein [IJV] is common and used for several clinical procedures. Internal jugular venous valves are the only barrier between the heart and the brain. The presence and structure of these valves is variously described in the literature. The purpose of the current study was to explore the presence of IJV valves, their location and structure

Methods: Observations for the unilateral or bilateral presence or absence, exact location and number of cusps of the IJV valves were recorded by dissection on 62 formalin-fixed adult male and female cadavers

Results: IJV valves were found in 76.62% subjects. Most common of these valves were bicuspid [68.54%] while the least common were the tricuspid valves [0.80%]. Unicuspid valves [collectively 7.25%] were more common on the right side in the male while the same was true for the females on the left side. Only one tricuspid valve was observed on the right side in a female. Valves were mostly inferior to the clavicle [54.73%] followed by posterior [38.94%] while the least common position was superior [6.31%].In the male the commonest location was inferior to the clavicle [70.00%] followed by posterior [28.33%] while in the female the more common location was posterior [57.14%] followed by inferior [28.57%]: the difference was significant. Superior position in the male was the least common [01.66%] while being relatively more common in the female [14.28%]: the gender difference was statistically significant

Conclusion: The prevalence of internal jugular venous valves, their types and location are variable and probably reflect a genetic and racial attribute

Relationship of human papilloma virus with trismus in chewable tobacco users

Background: Human Papilloma Virus [HPV] is found in the oral tobacco chewers with precancerous lesions such as submucous fibrosis [SMF], leukoplakia and erythroplakia. Trismus is a common symptom seen in patients with SMF and oral cancers. In Pakistan the risk of oral cancers has been raised up to 8.5 to 10 times due to increase in tobacco chewers in the recent years

Objective: To determine the frequency of oral HPV infection in chewable tobacco users with trismus living in the lowincome areas of Karachi

Methods: Camps were set up in 5 different areas of Karachi. In each camp, 100 people were examined for oral lesions by experienced volunteers. Oral rinse [40ml] was taken after gentle brushing over the lesions. DNA was extracted and PCR was performed using Gp5+/Gp6+ consensus primers. The results were analyzed on SPSS version 17.0

Results: Out of 187 subjects with trismus, 157 [84%] were males and 30 [15.51%] were females with average age of 28.7 years [12 -70 years]. Gutka, Naswar, Chalia and Paan users were 45.45%, 37.56%, 12.83% and 6.95% respectively. Mild trismus was found in 113 [60.43%] subjects followed by moderate trismus in 52 [27.81%] and severe trismus in 22[11.76%]. Out of total 36 [19%] HPV positive subjects, 27[14.44%], 7[3.74%] and 2[1.07%] had mild, moderate and severe trismus respectively. 150 controls tested negative for HPV

Conclusion: The frequency of HPV in oral cavity was high in subjects with trismus suggesting risk of oral squamous cell carcinoma. HPV in subjects with moderate to severe trismus should be tested in blood because it is difficult to get suitable oral sample

Diagnostic laparoscopy in the management of post appendectomy pain right iliac fossa

Objective: To determine the cause for pain right iliac fossa [RIF] after Appendectomy by Diagnostic laparoscopy in patients with normal investigations

Study Design: A Prospective Observational study

Place and Duration: Surgical A ward, Khyber Teaching Hospital Peshawar, from April 2009 to May 2011

Methodology: All those patient who continued to have pain in the RIF, more than 6 weeks after appendectomy,or more than 3 opd visits and normal investigations of genitourinary system and abdominopelvic ultrasound were included. Patients with symptoms of genitourinary system and pelvic inflammatory disease [PID] were excluded

Results: Fifty three patients were included in the study. Age range was from 15-42 years with 23 [43. 39%] patients aged less than 20 years, 15 [28.30%] 21-30 years,11 [20.75%] 31-40 years and 4 [7.54%] were above 40 years. Males were 19 [35.84%] and 34 [64.15%] were females, In 41 [77.35%] cases appendectomy had been done in emergency as they presented as acute appendicitis and 12 [22.64 %] were elective cases. Appendectomy was performed by open method in 45 cases [84.90%] and laparoscopically in 8 [15.09%] patients Diagnostic Laparoscopy was done in all patients and the findings included, adhesions in 21 cases [39.62%] tuberculosis in 9 cases [16.98%], PID in 7 cases [13.20%], ovarian cyst in 5 cases [9.43%] and a long appendicular stump in 2 [3.77%] and 1 [1.88%] terminal ileitis, while no cause was found in 8 [15.09%] patients

Conclusions: Post appendectomy pain RIF can be due to postoperative adhesions, pelvic inflammatory disease, ovarian cysts and abdominal tuberculosis. Diagnostic laparoscopy should be done to find out the cause in patients with inconclusive investigations

Synthesis of biologically active O-substituted derivatives of 1-[[3, 5-dichloro-2-hydroxyphenyl]sulfonyl]piperidine

In the present work, a series of 2-O-substituted derivatives of 1-[[3,5-dichloro-2-hydroxy phenyl] sulfonyl]piperidine [5a-j] were synthesized. These derivatives were geared up by the coupling of 3,5-dichloro-2-hydroxy benzenesulfonyl chloride [1] with piperidine [2] under dynamic pH control in aqueous media to form parent compound 1-[[3,5-dichloro-2-hydroxyphenyl]sulfonyl]piperidine [3], followed by the substitution at oxygen atom with different electrophiles [4a-j] in the presence of sodium hydride [NaH] and dimethyl formamide [DMF] to give a series of Osubstituted derivatives of sulfonamides bearing piperidine nucleus 5a-j. The synthesized O-substituted sulfonamides were spectrally characterized. The bioactivity of all the synthesized compounds were evaluated against lipoxygenase [LOX], acetylcholinesterae [AChE] and butyrylcholinesterase [BChE] enzymes and found to be having talented activity against butyrylcholinesterase enzyme

[Voiceless shout: parents' experience of caring for child with cerebral palsy]

Children with cerebral palsy need permanent care and attention in various stages of growth and development. The parents experience problems in taking care of these children and making them independent. This study was conducted to explore these experiences. This qualitative study was conducted in 2011-2012 using content analysis. Purposeful sampling was used to recruit 19 parents of children with cerebral palsy referred to rehabilitation centers in Tehran. The data were gathered using in-depth and semi-structured interviews and were analyzed inductively. Data analysis results revealed three original categories including "life with hardness" "being in ambiguity" and "need to be supported" and several subcategories including "physical strain" "psycho-emotional strain" financial burden" "restriction in social activities" "facing with anonymous" "lack of having an advisor" "need to get help from professionals and specialists" "need to have emotional- spiritual support" and "need to have help in caring the child". Parents in permanent care of children with cerebral palsy face with new and various situations consistently and experience difficulty and bewilderment because of insufficient family and social support. Further studies are needed to explore the support process of caregiver parents of these children

[Effect of Zataria multiflora boiss. essential oil on growth curve and shigatoxin 2 production of enterohemorrhagic Escherichia coli O157:H7]

Zataria multiflora Boiss. is one of the Iranian traditional spices and it has antimicrobial effect on the pathogenic bacteria which are agents for some current foodborne intoxications. The present study was conducted to evaluate the antimicrobial activity of Zataria multiflora Boiss. Essential oil on Escherichia coil 0157:H7. Minimum inhibitory concentration [MIC] and minimum bactericidal concentration [MBC] of Zataria multiflora Boiss. Essential oil [EO] for Escherichia coil 0157:H7 at 35°C, the effect of subinhibitory concentrations of EO on growth curve of bacteria up to 24 hours at 25 and 35°C and also production of shigatoxin 2 [Stx2], at 35°C has been determined. MIC and MBC of EO which have been evaluated were 0.04 and 0.06%, respectively the effect of subinhibitory concentrations of EO on bacterial growth curve during 24 hours has been determined by spectrophotometer device at 25 and 35°C and also production of shigatoxin 2 [Stx2], at 35°C has been determined. Subihibitory concentrations of EO, significantly, decreased the production of Stx2 at 35°C in a dose dependent manner. The results showed that Zataria multiflora Boiss. Essential oil had inhibitory effect on Escherichia coli 0157:H7 and it can be used as a natural preservative in food industry

Suitability of Gelucire 50/13 for controlled release formulation of salbutamol sulphate

Gelucire 50/13 [G50/13] was assessed to develop controlled release formulation of salbutamol sulphate [SBL] a highly water soluble drug by semisolid matrix filling capsule technique. Drug release profiles of SBL release by using G50/13 and its blends with other hydrophilic or hydrophobic materials were investigated. Lipid matrix formulations prepared with increasing amount of polymer showed a substantial decrease in release rate of the drug while increasing drug amount in fixed polymer concentration did not significantly affect the release profile. Polyethylene glycol 6000 caused an increased water uptake resulting in fast erosion of the matrix whereas cetostearyl alcohol and stearic acid caused retardation in drug release. These findings confirm that a considerable amount of Gelucire is required alone or in combination with hydrophobic substances in order to sustain the release profiles of water soluble drugs. More linear profile was obtained by using matrix comprising Gelucire/stearic acid blend in more than 85% that was comparable to standard, Ventolin SR tablet. The test formulation showed a significant decrease at pH 1.0 and the drug release rate increased at high stirring speed. Moreover, short term stability of controlled release test formulation indicated slight increase in dissolution rate at high temperature

Frequency of newly diagnosed diabetes mellitus in acute ischaemic stroke patients

To determine the frequency of newly diagnosed diabetes mellitus in acute ischaemic stroke patients. Observational study. Jinnah Postgraduate Medical Centre, Karachi, from June 2007 - June 2008. This study included adult patients [age > 30 years, both genders] with the diagnosis of acute ischaemic stroke. Patients who were known to have diabetes mellitus prior to stroke, had a non-lacunar stroke or were admitted to intensive care units for any reason were excluded. Detailed history and examination, fasting blood sugar, fasting lipid profile, a non-enhanced CT scan brain and electrocardiogram were done on every patient. Data were entered on a preformed proforma. The results were analyzed on SPSS version 10. Chi-square test was applied. P-value <0.05 was considered to be statistically significant. A total of 250 patients were enrolled. The male: female ratio was 1: 0.9. Mean age was observed as 60.9 +/- 10.1 years. In total, 50 new cases of diabetes mellitus were identified [20%]. Average fasting blood sugar in diabetic subjects was 148 +/- 10 mg/dl. The most common risk factors in the newly diagnosed diabetic subjects were hypertension 26 [52%], smoking 18 [36%] and hyperlipidemia 14 [28%]. Atrial fibrillation and myocardial infarction were seen in 12 subjects [24%] and 9 subjects [18%] respectively. Twenty percent patients with acute ischaemic stroke had un-diagnosed diabetes. Therefore, it is advisable to screen acute stroke patients for diabetes to reduce their long-term morbidity and mortality

[ Survey the effect of planned program of health promotion on stress management in middle-aged women]

There are many physiological and psychological stresses in Middle-age, which can have significant effect on mortality and suffering from a disease in women. So considering stress management in the form of a program is very important. This study aims at investigating effect of planned program of health promotion on stress management in middle-aged women. This research was a semi-experimental study and done with two groups of case [50 people] and control [41 people] were selected by convenience sampling. planned program of health promotion was performed on three stages: identification and investigation, supportive planning and evaluation of programs performing and giving feedback. Tools used to data collection in this research included: demographic information questionnaire and health promotion lifestyle profile 2 [HPLP2] questionnaires which completed by the case and control groups before and one and a half months after intervention. The finding showed that before intervention ,no meaningful important statistical difference was observed average numbers of stress management and spiritual improvement between case and control groups [P>0.05]. While after intervention according to independent t-test showed that there is a meaningful statistical difference in average numbers [P<0.05]. This difference was also meaningful before and after intervention in case group. Performing planned program of health promotion has been effective on stress management in middle-aged women and is suggested as a good program in mental health of middle-aged women

Outcome of open versus laproscopic appendicectomy in department of surgery, lady reading hospital, Peshawar

To compare safety and benefits of laparoscopic versus open appendicectomy in a randomized control clinical trial. Between January 2008 and October 2009 one hundred and twenty patients [86 male and 34 female] with suspected acute appendicitis were assigned either to laparoscopic [n=60] or open [n=60] appendicectomy. Surgical technique was standardized for both laparoscopic and open procedure. The patients were analyzed in terms of the following aspects and findings; operation time, postoperative pain, intra and post operative complications, hospital stay and return to normal daily activities. There was no mortality. Wound infection [8.3%] and intra-abdominal abscess [11.6%] formation rate was significantly higher in open group than in the laparoscopic group [1.6%] and [3.3%] respectively. Postoperative pain scores [assessed by a pain distress variable, indicated on visual linear scale 0 to 10 and a pain activity scale, indicated on visual linear scale 0 to 10] was significantly lower in laparoscopic group. Hospital stay was significantly shorter in laparoscopic group [p<0.0353] and mean operation time was similar in both groups. One patient [1.6%] was converted from laparoscopic to open appendicectomy due to diffuse pelvic adhesions. Though operation time was same but complications, pain and hospital stay was less in the Laparoscopic group

Influence of discharge planning on anxiety levels in patients with myocardial infarction

Nowadays, myocardial infarction is the second factor of the deaths after accidents and cancers in the world. The coronary artery diseases are stressful for patients. This research was performed to determine the influence of discharge planning on anxiety levels in acute myocardial infarction patients. This quasi-experimental study was performed on 60 patients with acute myocardial infarction at CCU [30 patients in each test and control groups]. The patients in the test group were received both routine intervention in their ward and designed discharge planning program based on the nursing process for 5 educational sessions at the hospital and followed up for 4- weeks in their homes; while, patients in the control group were received only routine intervention in their ward. The anxiety levels in myocardial infarction patients at the beginning of the hospitalization and one month after their discharge was measured by Spill Berger questionnaire. The independent t-test results showed that there is not a significant difference in the situational and total anxiety average scores of the patients in the test and control group before discharge planning. After applying discharge planning, there was a significant difference in the situational and total anxiety average scores of the patients in the test and control group [P<0.05]. Applying discharge planning for the patients with myocardial infarction resulted to decreasing their anxiety levels. Therefore, it suggests that the program of discharge planning to be used as a public plan based on an effective non-drug treatment and inexpensive method for reducing anxiety in patients who are suffering from acute myocardial infarction throughout the country

Palliative surgery for pancreatic carcinoma

To evaluate the role of palliative surgical treatment in patients with advanced pancreatic carcinoma. Case series. Surgical [D] Ward of Khyber Teaching Hospital, Peshawar, from January 2005 to January 2009. The study included patients with pancreatic carcinoma admitted with advanced, unresectable carcinoma of the pancreas. Patients with resectable tumours and with previous history of gastric or biliary surgery were excluded. Palliative procedures were performed after assessment of the tumour and its confirmation as unresectable on ultrasound and CT scan +/- ERCP. Postoperatively all patients were referred to oncologist. Complications and mortality were noted. There were 40 patients, including 24 males and 16 females with mean age 58.72 +/- 6.42 years. The most common procedure performed was triple bypass in 21 [52.50%] patients followed by choledocho-, cholecysto-, hepatico- and gastro-jejunostomy in various combinations. Wound infection occurred in 7 patients and was more common in patients with co-morbidities. Biliary leakage occurred in 03 patients. Postoperative cholangitis occurred in 3 patients while 7 patients had minor leak from the drain site. Four patients developed UTI, while 5 patients had signs of delayed gastric emptying. Two patients had upper gastrointestinal bleeding. Three patients died due to septicemia and multiple organs failure. Rest of the patients were discharged in stable state. The mean hospital stay was 8.40 +/- 3.48 days and median survival was 7.72 +/- 2.39 months. Surgical palliation for the advanced carcinoma pancreas can improve the quality of life of patients and is associated with minimum morbidity and mortality

Visual rehabilitation and intraocular pressure control after one site phacotrabeculectomy - an urban uni-center cross-sectional survey of Karachi, Pakistan

Cataract extraction and anti-glaucoma procedure together are regarded as an appropriate surgical intervention for co-existing uncontrolled glaucoma and visually significant cataract. Variety of surgical phacotrabeculectomy techniques have been proposed to reduce the frequency of complications and to solve the conflicting problems of water tight cataract incision and patient filtering glaucoma procedure. Our study will determine the visual recovery and intraocular pressure [IOP] control after single sitting phacoemulsification and trabeculectomy. The study is a comparative cross-sectional study. The participants included 50 patients randomly selected from out door patient department of Kulsoom Bai Valika Social Security SITE hospital, a tertiary care center. Routine one site phacotrabeculectomy was performed in all 50 patients and were followed over a period of 24 weeks. The data was entered on Statistical Package for Social Sciences [SPSS] Version 16 and analyzed. The pre-operative intraocular pressure [IOP] was 27.0 +/- 3.7, while the post-operative intraocular pressure [IOP] was 16.04 +/- 0.75 [p-value <0.0001]. The visual acuity which was evident [6/18] in 86% preoperatively and was reduced to 12% postoperatively [p-value <0.0001] while [6/9 - 6/12] visual acuity in the participants were 10% preoperatively and was improved in 80% postoperatively [p-value <0.0001]. Where as visual acuity [6/6] the participants were 4% preoperatively and 8% postoperatively [p-value <0.0001]