ABSTRACT
Introduction: Maternally Inherited Diabetes and Deafness(MIDD), a specific clinical syndrome results in sensory neuralhearing defect in diabetes population which may lead toA3243G mutation in tRNALeu (UUR) gene.Materials and methods: A prospective case control study, thenon probability convenient sampling technique was followedin this study. The subjects were divided into non diabetic anddiabetic with maternal inheritance groups. Hundred patientswith the strong maternal history of diabetes is group 1 andhundred non diabetic individuals with no maternal history ofdiabetes is group 2. Blood and urine samples were collectedand analyzed biochemical parameters among the two groups.In addition, audiometric analysis was also carried out for thosegroups.Results: The mean age of onset of diabetes was 41 yearsand deafness was 51 years. The mean plasma glucose,Glycosylated Hemoglobin(HbA1C), Serum Insulin, InsulinResistance, Cholesterol, Triacyl glycerides, Very Low DensityLipoprotein(VLDL), Low Density Lipoprotein, SerumUrea, Serum Uric acid, Serum Creatinine and Albumin toCreatinine Ratio (ACR) levels in patients were significantlyhigher whereas High Density Lipoproteins(HDL) and urinecreatinine levels were significantly low as compared withcontrols. The mean Body Mass Index (BMI) is slightly higherin patients as compared with control group.Conclusion: The study helps us to understand that theMaternally Inherited Diabetes and Deafness syndromeseverely alters the insulin resistance level, ACR ratio and lipidprofile which may lead to multiple organ disorder at early ageof diabetes.
ABSTRACT
Obesity by itself is not an immediate lethal disease, however, it is a significant risk factor associated with a range of serious noncommunicable diseases. Our aim is to find out the prevalence of metabolic syndrome in interns coming from higher socioeconomic class. Sixty one interns participated in the study. BMI, WHR and blood chemistry were performed. EGIR criteria were considered to identify the metabolic syndrome. According to EGIR criteria, insulin resistance was found in 24.5% cases and metabolic syndrome exists in 14.7% of overweight/obese interns. Insulin resistance as per HOMA-IR was found in 6% of those having metabolic syndrome. High diastolic blood pressure, low HDLc are prone to develop metabolic syndrome by six times where as an increase in WHR (central obesity) particularly in male are eleven times more prone to develop metabolic syndrome. Abbreviations :–EGIR – European Group for Insulin Resistance, HOMAIR – Homeostasis model assessment for insulin resistance (HOMA-IR), WHR – waist hip ratio. HDLc–HDL cholesterol.
ABSTRACT
OBJECTIVE: To assess the status of iodine deficiency in Pondicherry by finding out the urinary excretion of iodine and the prevalence of goiter among school children. METHODS: 315 children between the age group of 9-13 yr from 30 schools in Pondicherry were examined for the presence of goiter and their urine samples were subjected to biochemical analysis to find out the urinary iodine levels (UIE). RESULTS: The percentage of children who had inadequate iodine intake and showed urinary iodine level of less than 100 mcg/ L was 44.4%. Amongst them, 14.3% had a greater degree of iodine deficiency with less than 50 mcg/L of iodine in urine. The prevalence of goiter was 15.24%. CONCLUSION: The prevalence of goiter is high. The iodine intake is quite low as exhibited by the UIE levels of < 100mcg/L in the children in Pondicherry, which might have had an unseen impact on the intelligence and school performance of these children.