ABSTRACT
To study the cytogenetic profile of newly diagnosed patients with pediatric acute lymphoblastic leukemia [ALL]. Prospective case control study. Tertiary care hospital in India. Newly diagnosed patients with pediatric ALL. Karyotype analysis of bone marrow aspirate samples by routine G-Banding technique and analysis as per International System for Cytogenetic Nomenclature [ISCN], 2005 criteria. Cytogenetic parameters. The study included 23 male and eight female patients [M:F = 2.8:1]. ALL-L2 was the most common morphlogical phenotype [18 / 31, 58%]. Sixteen out of thirty one [51.6%] patients were hypodiploid [2n < 46], 10 / 31 [32.0%] hyperdiploid [2n >46] and 5/ 31 [16.0%] aneuploid. Among hypodiploid groups, nine [29.0%] had modal chromosome number as 40-45, five [16.0%] as 31-39 and two [6.5%] as 25-30. Among hyperdiploid group, 7 [22.5%] had modal chromosome number as 51-60 followed by 2n = 47-50 [three patients, 6.5%]. The chromosomes [Chr] 2, 10, 12, 15, 17, 19 gain of Chr 4, 8, 10, 14 and 20 were observed in hyperdiploid group. Translocation t [10;14], t [9;22], t [2;22], t [8;22] and t [4;11] were seen in 04 [12.8%], 03 [9.6%], 02 [6.4% each] and one patient [3.2%] respectively. Adverse cytogenetic parameters such as hypodiploidy and translocations such as t [10;14], t [9;22], t [2;22], t [8;22] and t [4;11] were more common in our cohort of patients
Subject(s)
Humans , Male , Female , Chromosome Aberrations , Aneuploidy , Case-Control Studies , Prospective StudiesABSTRACT
Aspergillosis of central nervous system is an uncommon infection mainly occurring in immunocompromised patient. It may be present in several forms: abscess, meningitis, mycotic aneurysm, infarction and in tumoral form. Here we report a case of cerebral aspergillosis presenting as bilateral frontal lobe abscess without evidence of any underlying systemic disorder or extracranial disease.
Subject(s)
Aspergillus/isolation & purification , Brain Abscess/microbiology , Central Nervous System Fungal Infections/microbiology , Humans , Immunocompromised Host , Male , Middle Aged , Neuroaspergillosis/microbiology , Tomography, X-Ray ComputedABSTRACT
Endovascular papillary angioendothelioma (EPA) is a rare vascular tumor of low grade malignancy, encountered primarily in children. However some cases have also been reported in adults. A sixty year old female with EPA is described here. She presented with a swelling in the neck. Total surgical excision was performed. Histomorphology revealed anastomosing lymphatic channels showing intraluminal papillary fronds with hyaline vascular cores and hobnailing of endothelial cells. A diagnosis of EPA was made based on this picture. This tumor is recurrent and nodal metastasis has been reported in some cases.
Subject(s)
Diagnosis, Differential , Female , Head and Neck Neoplasms/diagnosis , Hemangioendothelioma/diagnosis , Humans , Middle Aged , Neck/pathologyABSTRACT
Haemangioblastoma is a rare benign vascular tumor commonly seen in the cerebellum. There is a striking histologic similarity between cellular variant of haemangioblastoma and metastatic renal cell carcinoma. We present a case of haemangioblastoma in a 32-year-old male. Histology revealed a highly vascular tumor composed of clear cells in a lobular arrangement.
Subject(s)
Adult , Carcinoma, Renal Cell/diagnosis , Cerebellar Neoplasms/diagnosis , Cerebellum/pathology , Diagnosis, Differential , Hemangioblastoma/diagnosis , Humans , MaleABSTRACT
Plasma cell leukemia (PCL) is a rare type of plasma cell dyscrasia. It is diagnosed when circulating plasma cells (PC) are more than 20%. We present a case of PCL in a 62-year-old female. Peripheral smear revealed more than 80% atypical vacuolated plasma cells (Mott cells) almost mimicking Burkitt cells of Acute Lymphoid Leukemia-L3 (ALL-L3). Bone marrow aspirate revealed few mature myeloma cells for which a diagnosis of PCL was thought of. Serum electrophoresis showed a positive M-band and X-ray revealed lytic lesions over femur & pelvic bones. A final diagnosis of PCL was given.