ABSTRACT
Myocardial infarction with normal coronary artery is usually inaugural, with electric and clinical characteristics similar to those with atheroma. The role of constitutional or acquired abnormalities of haemostasis has been more incriminated in the pathogenesis of myocardial infarction with normal coronary. The aim of our study was to research abnormalities of haemostasis in patients with myocardial infarction and angiographically absolutely normal coronary arteries. Thirty nine, patients with myocarcdial infarction and normal coronary arteries were included in our study. They were 33 males and 6 females aged between 22 and 75 years [44 +13 years], in whom the deficiency in protein C and S. antithrombin, activated protein C resistance and antiphospholipid antibodies were assessed Concurrent abnormalities of haemostasis were found in 10 patients: Antiphospholipid antibodies, found in 5 patients constitute the most frequent abnormality. The other abnormalities were deficiency in protein C in two cases, deficiency in protein S 2 cases, deficiency in antithrombin in 2 cases and activated protein C resistance in 3 cases In our study, in face of the high prevalence of these abnormalities, it seems reasonable to research them, especially in young patients with myocardial infarction with normal coronary artery. This should have an impact on the management of these patients
Subject(s)
Humans , Male , Female , Homeostasis , Coronary Angiography , Coronary Vessels , Antibodies, Antiphospholipid , Protein C Deficiency , Protein S Deficiency , Antithrombins/deficiency , Activated Protein C ResistanceABSTRACT
Research of abnormality of heamostasis in thromboembolic disease is very important. In this work, we have studied resistance to activated protein C. Antithrombin III, Protein C, protein S and anticardiolipin antibody in 30 patients who have past history of arterial and venous thrombosis, and in a control population of 25 healthy subjects. We have reported one case [4%] of resistance to activated protein C in healthy subjects and 6 cases [20%] in patients; 4 deficiences of antithrombin III, I deficiency of protein S, and 3 patients with anticardiolipin antibody. The clinical entity of these abnormalities of heamostasis between resistance to activated protein C and deficiencies of coagulation physiologic inhibitors