ABSTRACT
Objectives: The current study aimed at comparing the efficacy of Clomiphene Citrate [CC] for the expectant management of unexplained infertility in females over 3 successive cycles
Materials: The present randomized, controlled, clinical trial was carried out at Ain Shams University Maternity Hospital. Females with unexplained infertility for at least 12 months of unprotected regular marital life were enrolled. Eligible females were randomly assigned into one of the 2 following groups: group 1 received 100 mg CC once a day for 5 days, and group 2 was expectantly followed up without induction of ovulation. The primary outcome was the clinical pregnancy rate
Results: A total of 113 females were enrolled in the current trial. The mean age of the subjects was 25.3+/-3.1 years; ranged 20 to 33. The clinical pregnancy rate was slightly, but significantly, higher in CC group compared with the controls; both per case [7/57 vs. 4/56, 12.3% vs. 7.1%, respectively; P=0.357; Relative Risk [RR]=1.72; 95% Confidence Interval [CI]=0.53, 5.55; Number Needed to Treat [NNT]=19] and per cycle [7/163 vs. 4/160, 4.3% vs. 2.5%, respectively; P=0.374; RR=1.72; 95% CI=0.51, 5.75; NNT=56]
Discussion: CC seems to be not effective in improving clinical pregnancy outcome compared with observation alone in females with unexplained infertility
ABSTRACT
Compounds having the general formulae [VI] and [IX] have been efficiently prepared from 2-arylaminonicotinic acid hydrazide IV. Group VI was prepared by the condensation of IV with various carbonyl compounds to give the arylidene hydrazides V, which underwent cyclization to the corresponding oxadizolines VI with acctic anhydride. Additionally, compounds VIII, obtained through cyclization of the corresponding thiosemicarbazide VII, were reacted with 1,2- dibromoethane giving the thiazolo [3 2-b]-s- triazoie derivatives IX. Seven compounds were subjected in vitro testing and most of them exhibit noticeable antibacterial activity