Association of ABO blood group b with myocardial infarction

The purpose of this study was to find out the association between blood group B and Myocardial Infarction [Ml] in sample population in Malaysia. A case-control study. The study was conducted at Hospital Kepala Batas, Penang, Malaysia, from 2006 to 2007. The study was approved by the Research and Ethics Committee, School of Medical Sciences, University Sains Malaysia. The study included 170 patients with confirmed Ml as cases and 170 subjects without Ml were taken as controls. After ethical approval, patients were recruited for the study from Hospital Kepala Batas after informed consent. Blood sample around 2 ml was collected from each patient and control. Each blood sample was tested by ABO gel card test for the blood group. Sample size was calculated using a power and sample size software, whereby power of study was 80%, Confidence Interval [Cl] was 95%, odds ratio was 2 and ratio of control to case was 1. Odds ratio and the Cl were used to describe the association between Ml and group B. A total of 170 Ml patients and 170 controls were tested for ABO blood groups. Statistical analysis showed that among 170 Ml subjects, 54 [31.8%] were blood group B and among 170 controls, 51 [30%] were blood group B. Simple logistic regression analysis showed no association of Ml with blood group B [p=0.824, crude OR 0.95, 95% confidence interval 0.62-1.47]. Multiple logistic regression analysis also did not show association of blood group B with Ml [p=0.222, adjusted OR 0.68, 95% confidence interval 0.37-1.26]. This study failed to demonstrate any association of blood group B with Ml in sample population in Malaysia compared to few studies reporting positive association, however, we suggest further studies to elaborate on this finding in Malaysian population

Age specific histologic types of carcinoma breast in Malaysians

The influence of age on various histological types of breast cancer at both age < 50 years and > 50 years to simulate menopause was studied retrospective from 2002 to 2004 in Malaysia. One hundred and fifty five cases were reviewed. Ninety two cases recorded at age < 50 years, 60 [65.2%, 95%CI: 54.6 - 74.8%] were infiltrating ductal carcinoma in 11[12.0%, 95% CI: 6.1-20.4%], ductal carcinoma in situ [DCIS] in 9 [9.8%, 95% CI: 4.6-17.8%], medullary carcinoma in 6 [6.5%, 85%CI: 2.4-13.6%], invasive lobular carcinoma in 4 [4.3%, 95%CI: 1.2-10.8%], mucinous carcinoma and poorly differentiated carcinoma in 2 cases [2.2%, 95%CI: 0.3-7.6%]. At > 50 years of age, 63 cases were recorded. Forty seven [74.6%, 95%CI: 62.0- 84.7%] cases were of infiltrating ductal carcinoma, ductal carcinoma in situ in 9 [14.3%, 95%CI: 6.7-25.4%], mucinous carcinoma in 5 [7.9%, 95%CI: 2.6-17.6%], medullary carcinoma [8.5%] and papillary carcinoma in 1 case each [1.6%, 95%CI: 0.0-8.5%]. Infiltrating ductal carcinoma was the commonest histology at both age < 50 years and > 50 years

Hereditary spherocytosis in a Malay patient with chronic haemolysis

This case report describes a 35-year-old lady who presented with generalized weakness and lethargy of two weeks duration and jaundice of more than 20 years duration. Her initial workup was suggestive of haemolysis and blood film showed a leucoerythoblastic picture with moderate microspherocytes. She was finally diagnosed as a case of hereditary spherocytosis after ruling out other possible causes of chronic haemolysis and supported by an abnormal osmotic fragility test, although family members refused for screening. Hereditory spherocytosis is uncommon in Malay population and presentation with jaundice of 20 years duration with leucoerythroblastic picture on blood film were interesting features in this case. Patient is being followed closely for need of splenectomy in near future as per severity of haemolysis and currently being managed with folic acid supplement.

Bone involvement in hodgkin's disease at presentation: a series of three case reports with a brief review

Most patients with Hodgkin's lymphoma present with the disease. On staging workup, all the three patients progressive painless lymphadenopathy. Very few patients were found to have bony lesions at the time of diagnosis, have presented with bony involvement at the time of confirmed by imaging studies. All patients were treated diagnosis. We report on three cases of Hodgkin's with chemotherapy and radiotherapy directed at their lymphoma who presented with signs and symptoms of bony lesions. bone involvement in addition to other clinical features of the disease on rtaging work up, all the three patients were found to have bonylerions at the time of cliagnosin confivmed by imaging rtudgies. all patients were treated with chemotheraby and radio theraty directed at their bany lesions