ABSTRACT
Chronic Periodontitis is accompanied with subacute systemic inflammatory responses and a procoagulant state which manifests in changes of some serological vascular thrombotic markers levels. This study aimed to evaluate several vascular thrombotic markers levels in patients with chronic periodontitis. Study population consisted of 60 individuals ,36 males, 24 females, aged between 30- 48 years, [mean 36.33 years], were divided into 2 groups; the first, [n=20],was the control healthy individuals, and the second, [n=40],was patients with chronic periodontitis. Registration included, systolic blood pressure[sBP], body mass index and the periodontal disease indices; dental plaque[PI], gingival inflammation[GI], bleeding on probing[BOP], pocket probing depth[PPD],clinical attachment loss[CAL]. Blood tests included platelets count[Plt], fibrinogen[Fib], prothrombin time[PT], activated partial thromboplastin [aPTT], and Von Willebrand factor antigen [vWF:Ag]. Statistics, included independent Ttest and Pearson correlation, were performed at [P<0.05] by means of SPSS 19th ed. There were significant differences between the two groups in [sBP] [P=0.022], [Plt] [P=0.004], [Fib] [P=0.001], [vWF:Ag] [P=0.011], and in all of the periodontal indices [P<0.05]. Furthermore, there was a significant moderate positive correlation [r= 0.4, P<0.05] between all of the periodontal indices thrombotic markers, and was more evident in [Plt] with [GI], [Fib] with [PI], [GI], [BOP], [PPD], and [vWF:Ag] with [PI]. Periodontitis was associated with higher values of systolic blood pressure, platelets count, fibrinogen level, Von Willebrand factor activity, and periodontal indices positively correlated with the thrombotic markers. These findings would point out to the role of the periodontal disease as a risk indicator in precipitating a procoagulant state
ABSTRACT
Recent studies has focused on the impact of periodontal disease on the general health like cardiovascular disease and hypertension and their interactions. We aimed to study several vascular thrombotic markers levels in patients with chronic periodontitis and hypertension. Study population consisted of 80 patients aged 30- 68 years, [mean 43.7 years], [53 males, 27 females], were divided into 2 groups; the first, [n=40], had only chronic periodontitis, and the second,[n=40], were hypertensives with chronic periodontitis. Registrations included systolic blood pressure] [sBP], body mass index[BMI], and periodontal disease indices; dental plaque [PI], gingival inflammation [GI], bleeding on probing [BOP], and clinical attachment loss [CAL] Blood tests included; platelets count [Plt], fibrinogen [Fib], prothrombin time [PT], activated partial thromboplastin [aPTT], and Von Willebrand factor antigen [vWF:Ag]. Independent T-test and Pearson correlation, were performed at [P<0.05] by means of SPSS 19th ed. Hypertensives with periodontitis showed higher significant differences in age [P=0.001], [sBP] [P=0.001], [FBG] [P=0.001] [Plt] [P=0.022], [Fib] [P=0.001], and in [PPD] [P=0.008], [CAL] [P=0.001]. Significant moderate positive correlation was found between [Plt] and both of [PPD] and [CAL], while [Fib] correlated with[CAL], [r= 0,3- P<0.05]. Periodontitis in hypertensives was associated with an elevation in platelets count and fibrinogen concomitantly with an increase in blood glucose levels and body mass index,in addition to greater pocket probing depth and clinical attachment loss, compared with periodontitis only.These results shed the light on periodontitis as a risk indicator for hypertension and thrombotic propensity in susceptible individuals