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Indian J Physiol Pharmacol ; 1980 Jan-Mar; 24(1): 61-4
Article in English | IMSEAR | ID: sea-107052

ABSTRACT

Whole venom Dendroaspis angusticeps produced a negative chronotropic and ionotropic effect on the heart. Isolation of the fraction (T39) produced the same effect. Negative inotropic effect was blocked by atropine. The bradycardia may be due to a cholinergic effect and the negative ionotropic to a direct depressant effect on the myocardium.


Subject(s)
Animals , Atropine/pharmacology , Depression, Chemical , Elapid Venoms/pharmacology , Heart Rate/drug effects , Myocardial Contraction/drug effects , Rabbits , Time Factors
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