ABSTRACT
Twenty-five patients with advanced or recurrent breast carcinoma refractory to hormonal and or previous chemotherapy were treated with combination of ifosfamide, methotrexate and 5-fluorouracil with Urometexan. Courses were repeated every 3 weeks. The 24 evaluable patients received 3-12 courses with an average of 5 courses. There was complete remission in 3 patients [12.5%] and 3 [12.5%] partial remissions. Improvement was detected in 4 [16.6%] and stablization of disease in 7 [29.2%]. The over all response rate [CR+PR] was an average of 5 courses. There was complete remission in 3 patients [12.5%] Toxicity was minimal and mostly gastrointestinal 17/24, alopecia 12/24 and Leucopenia 6/24. The combination of Ifosfamide, methotrexate and fluorouracil is effective second line treatment in breast carcinoma
Subject(s)
Neoplasm Metastasis , Neoplasm Recurrence, Local , Drug Therapy, CombinationABSTRACT
Forty three patients in stage III and IV malignant lymphoma [17 H.D. and 26 N.H.L] were investigated in this study for presence of paraproteins in their sera and subsequently of clinical manifestations of paraproteinaemia. Twenty nine of them were males and 14 were females. Their ages ranged between 15 and 65 years. Twenty one [48.8%] presented with one or more of the clinical manifestations related to paraproteins in their sera: cold urticaria was detected in 12 occasions, purpura in 8, chilblains in 6. tingling and numbness in 4, Chronic leg ulcers in 4, acrocyanosis in 2, vasculitis and Raynaud's phenomenon each in one occasion. Qualitative and quantitative determination of the different types of paraproteins was performed. Cryoglobulin was found in the sera of 30 patients [69.7%]. paraglobulin was detected in 14 patients [32.5%]. Simple type of cryoglobulin [mostly of IgG] was present in 19 patients and mixed type [IgG and IgM] in 11 patients and both types were more frequent in females. Cold urticaria, purpura, chilbains and chronic leg ulcers were associated with simple cryoglobulins in most occasions, while patients complaining of tingling sensation and numbness, acrocyanosis and vasculitis had mostly mixed cryoglobulins. Pyroglobulin have no clinical significance, yet it was associated with high level of cryoglobulin. Hypoalbuminaemia was detected in 56% of cases. The main disturbance in globulin was elevation in total globulin, alpha-1 and gamma fractions. Hypergammaglobulinaemia was marked in H.D. [88.1%] than N.H.L. patients [34.6%]. Chemotherapy treatment showed decrease in cryoglobulin level in some cases, while there was an obvious increase in the albumin, normalisation of globulin and improvement in the general condition of patients