ABSTRACT
The effect of a treadmill running program on the metabolism of cholesterol in serum and in arterial wall was studied in male Wistar rats, aged 7 weeks and weighing about 200 g- Rats were exercised on 6 days a week for 8 week, running 1, 000 m a day at 15 m/min. The trained rats gave the follwing evidence, as compared with the sedentary control animals:<BR>1. Remarkably lower body weight<BR>2. Significantly lower level of serum cholesterol-total, free, and LDL cholesterol<BR>3. Elevated in vivo incorporation of <SUP>14</SUP>C-mevalonate into serum cholesterol<BR>4. Enhancement of lecithin-cholesterol acyltransferase activity in serum<BR>5. Decrease in the amount of cholesterol in arterial wall cells<BR>6. Increase in in vivo incorporation of <SUP>14</SUP>C-mevalonate into arterial cholesterol.<BR>The results indicate that the excersice promotes the turnover of cholesterol in serum and arterial wall, repressing the accumulation of choleterol ester in arterial wall cells, and a prophylactic effect of the physical training for arteriosclerotic diseases has been suggested.
ABSTRACT
The effect of a treadmill running program on the metabolism of cholesterol in liver was studied in male Wistar rats, aged 7 weeks and weighing about 200 g. Rats were exercised on 6 days a week for 8 weeks, running 1, 000 m a day at 15 m/min. The trained rats gave following evidence, as compared with the sedentary control animals:<BR>1. Remarkable lower weight of body and liver<BR>2. Significantly lower level of total and free cholesterol in liver<BR>3. Elevated in vivo incorporation of<SUP>14</SUP>C-acetate and of<SUP>14</SUP>C-mevalonate into liver cholesterol<BR>4. Enhanced incorporation of<SUP>14</SUP>C-mevalonate into cholesterol by liver slice<BR>5. Increased activity of hydroxymethylglutaryl-coenzyme A reductase in liver<BR>6. Increase in cholesterol 7 a-hydroxylase activity in liver<BR>The results indicate that the exercise promotes the turnover of cholesterol in liver.