ABSTRACT
The hepatoprotective activity of the ethanol extract of Astragalus kahiricus (Fabaceae) roots against ethanol-induced liver apoptosis was evaluated and it showed very promising hepatoprotective actions through different mechanisms. The extract counteracted the ethanol-induced liver enzymes leakage and glutathione depletion. In addition, it demonstrated anti-apoptotic effects against caspase-3 activation and DNA fragmentation that were confirmed by liver histopathological examination. Moreover, the phytochemical study of this extract led to the isolation of four cycloartane-type triterpenes identified as astrasieversianin II (1), astramembrannin II (2), astrasieversianin XIV (3), and cycloastragenol (4). The structures of these isolates were established by HRESI-MS and 1D and 2D NMR experiments. The antimicrobial, antimalarial, and cytotoxic activities of the isolates were further evaluated, but none of them showed any activity.
Subject(s)
Animals , Female , Humans , Rats , Apoptosis , Astragalus Plant , Chemistry , Caspase 3 , Metabolism , Chemical and Drug Induced Liver Injury , Drug Therapy , Genetics , DNA Fragmentation , Ethanol , Toxicity , Liver , Cell Biology , Plant Extracts , Plant Roots , Chemistry , Protective Agents , Rats, Sprague-DawleyABSTRACT
The macro- and micromorphology of the leaf, stem and root of Phlomis floccosa D. Don. Are presented, with are presented, with the aim of finding out characters by which the plant could be identified and differentiated from the other species growing in Egypt
ABSTRACT
The macro-and micromorphological characters of the flower of Phlomis floccosa D. Don. [Lamiaceae], growing in Egypt are presented
ABSTRACT
The macro- and micromorphological characters of the leaves, stems and fruits of Phlomis aurea Decne growing in Egypt, are presented with the aim of finding out characters, by which the plant could be identified and differentiated from other closely related species
Subject(s)
PharmacognosyABSTRACT
The macro- and micromorphological characters of the flower of Phlomis aurea Decne growing in Egypt are presented with the aim of finding out the characters of this diagnostic organ, by which it could be identified in both the entire and powdered forms
Subject(s)
PharmacognosyABSTRACT
The macro- and micromorphological characters of the flower heads of Tanacetum santolinoides [DC.] grown in Egypt, are presented with the aim of finding out the characters of this diagnostic organ, by which it could be identified in both the entire and powdered forms
Subject(s)
PharmacognosyABSTRACT
The macro- and micromorphological characters of the leaves, stems and rootstocks of Tanacetum santolinoides [DC.] grown in Egypt, are presented with the aim of finding out characters by which the plant could be identified and differential from other closely related species