Evaluation on the therapeutic effects of Che day in the treatment for gastro-duodenal ulcer in clinical, endoscopy and pathological anatomy

Background: Che day is a commonly used traditional medicine among the mountainous ethnic people to treat gastro-duodenal ulcer. Its scientific name is Ampelopsis Cantoniensis Planch (Vitaceae). It is known that chemical components of che day includes flavonoid, tanin and uronic compound, which is able to relieve pain completely. Objectives: Evaluation of analgesic, cicatrisation, anti-inflammation and Helicobacter Pylori (HP) eradicating effects of che day in the treatment of gastro-duodenal ulcer and also investigate the side effects of che day. Subject and methods: 80 patients with gastro-duodenal ulcers were seen with endoscopy, suffering from epigastric pain. The study was carried out in the way of a double - blind method, comparing the results between the group che day and the Alusi cotrolled group. Results: On average, the time when the pain receded is 8.9 days in the che day group, faster than the Alusi controlled group (17.35 days, p < 0.01). The rate of the cicatrisation by che day is 79.55%, higher than the Alusi (47.22%; p < 0.001). In pathological anatomy, the rate of HP eradicating of che day is 42.5%, higher than the Alusi (19.35%, p < 0.01); the rate of recovery from gastritis of che day is 23.25%, higher than the Alusi (9.09%, p < 0.01) and the rate of total recovery of che day is 44.19%, higher than the Alusi; (27.27%, p < 0.01), Conclusions: The che day is effective in relieving gastro-duodenal ulcer \u2013 induced pain for the average of 9 days. In endoscopy, the rate of cicatrisation of che day is 79.55%, in which, good cicatrisation is 54.28%. In pathological anatomy, the che day is effective in eridicating HP with the rate of 42.5 %; The rate of recovery is 23.25% and che day has no side effects.

Histopathology of gastric mucous membrane in patients with duodenal ulcer before and after treatment with Che day (Ampelopsis Cantoniensis Planch)

Introduction: Che day (Ampelopsis Cantoniensis Planch) is a medicinal herb that has been used for a long time in Vietnamese Traditional Medicine for treating gastroduodenal ulcer. Scientific studies found that Che day has some chemical components such as flavonoids, tannins and uronic compounds that can neutralize the gastric acidity. Objectives: This study was conducted with the aim of evaluating the H pylori eradication ability and the anti-inflammation properties of Che day for duodenal ulcer, using histopathological measures. Subjects and method: 43 patients with endoscopy-confirmed diagnosis of duodenal ulcer were involved in the opening clinical trial. Ages of patients were ranged from 18 to 65 years old. The patients were treated for 6 weeks by dried extracts of Che day (four 5gr-sachets divided into 4 times a day) and underwent endoscopic biopsy before and post-treatment. Results: Che day had the HP eradication effect in 17/43 patients (42.5%), as seen in histophathological examinations. This results were significant with p <0.001. The rate of recovering patients reached up to 23.26% (10/43 patients) and the rate of severe cases reduced dramatically (18/20 patients). The comparison before and after 6 weeks of treatment showed the prevention effect of Che day from gastritis with statistic significance (p<0.001). Conclusion: Che day has the HP eradication ability with the rate reaching up to 42.5%. This herb reduced the gastritis in histopathological studies. 23.26% of patients recovered from duodenal ulcer after treatment and the severe cases were dramatically reduced.