Evaluation of the effect of the essential fatty acid on cancer induced in cheek buccal mucosa in rabbits

The aim of this study was to evaluate the effect of the essential fatty acid, linoleic acid, and its metabolic intermediate gamma-linoleic acid in the treatment of squamous cell carcinoma chemically induced in the cheek mucosa of the rabbits. The study was carried out on 10 rabbits of the same species. Cancer is induced by injection of 0.2 ml of 1% DMBA in paraffin oil into the cheek of the rabbits. The injected dose of DMBA was increased by 0.1 ml to attain a total of 0.5 ml, when histological examination confirms the development of cancer, treatment started with primose oil and corn oil in diet. A small swelling started to appear intraorally with fungated mass extraorally after four weeks from injection, with loss of body weight. As a result of treatment with PO the general condition of the rabbits improved with an increase in body weight and with shrinkage in size of the mass. The histological examination revealed epithelization of the ulcer at the end of follow up period with evidence of fibrosis. Primose oil and fatty acids can control local growth and dissemination of malignant cells

Tissue response to a kaltostat wound dressing in tooth extraction in diabetes

The purpose of the present work was to study the effect of kaltostat on the healing process after tooth extraction in guinea pigs with induced diabetes. Nine guinea pigs were used after induction of diabetes by a single subcutaneous injection of a freshly prepared Alloxan mono-hydrate in saline solution. The animals were considered definitely diabetic only when the non-fasting blood sugar level was above 180 mg%. So, it was recommended to use the kaltostat in diabetic patients after teeth extraction in combination with any systemic prophylactic antibiotics to avoid the development of fibrinolytic alveolitis and to accelerate the healing process without expecting any harmful side effects