Levels of serum intercellular and vascular adhesion molecules in insulin dependent diabetic nephropathy patients

The study evaluated the possible significant role of soluble intercellular and vascular adhesion molecule- 1 [sICAM-1 and sVCAM-1], sE-selectin and interluekin-l beta in development nephropathy in patients with insulin dependent diabetes mellitus [IDDM]. This study included 60 patients with type 1 diabetes mellitus [IDDM], together with 20 healthy control subjects. Patients were divided into 3 groups according to the onset of disease. All studied groups were subjected to clinical and laboratory evaluation of serum soluble sIC AM- 1, sVCAM-1, sE-selectin, IL-l beta in association with microalbumin, and CRP. A highly significant elevation of soluble adhesion molecules [sICAM-1, sVCAM -1 and sE-selectin] and microalbuminuria were observed in patients with IDDM, while there was no significance difference in ILl-beta in the same patients. Our findings may have clinical implications, since they may indicate that, these adhesion molecules are known as very strong marker for renal complications and the circulating forms of these adhesion molecules have been associated with clinical vascular events and all-cause mortality in the renal population

Urinary thromboxane B2: a new predicting marker for acute myocardial infarction in subjects with risk factors

The authors evaluated the possible significant role of urinary TXB2 as a new predicting marker of Acute Myocardial Infarction [AMI] in high-risk subjects. Eighty persons were submitted to this study and divided into three groups, the control group [n = 20], the high risk group [n = 30] and the AMI group [n =30]. all persons subjected to clinical and laboratory evaluation: Cardiac enzymes, Myoglobin, Lipid profiles, Pyruvate Kinase and urinary TXB2 level. A high significant elevation of Cardiac enzymes, Myoglobin and Pyruvate Kinase was observed in AMI group only. Urinary TXB2 in risk group was highly significant elevated while in AMI group was non significant increased compared to control group the Urinary TXB2 could be used as a good predicting marker for probability of AMI in patients who had one or more of the AMI risk factors