ABSTRACT
Whole venom Dendroaspis angusticeps produced a negative chronotropic and ionotropic effect on the heart. Isolation of the fraction (T39) produced the same effect. Negative inotropic effect was blocked by atropine. The bradycardia may be due to a cholinergic effect and the negative ionotropic to a direct depressant effect on the myocardium.
Subject(s)
Animals , Atropine/pharmacology , Depression, Chemical , Elapid Venoms/pharmacology , Heart Rate/drug effects , Myocardial Contraction/drug effects , Rabbits , Time FactorsABSTRACT
Aconitine, 10 mug, administered intraventricularly in cats produced cardiae arrhythmias. Intraventricular administration of phenoxybenzamine, propranolol and practolol abolishes the centrally induced cardiac arrhythmias. Intraventricular reserpinization also abolished these cardiac arrhythmias whereas intraventricular administration of 6-hydroxydopamine and tetrabenazine had no effect. Brain stem noradrenaline probably plays a role in these centrally induced cardiac arrhythmias by aconitine.