Treatment of the bone marrow failure in the Ho Chi Minh center for hematology and blood transfusion

From 1990 to 2000, 513 cases of aplastic anemia were diagnosed and treated in Blood transfusion and Hematology Centre of Ho Chi Minh city, composing of 144 children and 369 adults with 279 males and 234 females. By bone marrow aspiration and biopsy, we diagnosed these cases as follow: aplastic anemia 449 cases (87.5%), hypocellularity of bone marrow: 45 (8.8%), one lignea hypocellularity of bone marrow: 19 (3.7%). From these cases, we have found that: - ’s difficult to point out accurately the cause of aplastic anemia and this is still the question for many studies in future. - All the patient was treated mainly blood transfusion, corticoid and androgen (77.5%) with complete and partial response was 25.5%. Besides, 32 cases were treated with corticoid + Sandimum given better results with complete response (32.7%).

Finding of the congenital factor VII deficiency

This 29 years old woman was admitted to the hospital with menstrual and dental bleeding. Physical examination revealed a pale brust on the legs. Laboratory data. - Hemograme: Hb: 7.5 g/dl, Hct: 22.7%, RBC: 2.86 x 1012/ l, WBC: 57.109/l hemostatic: PT: 23“7 (10”9), INR 5.86, aPTT: 32” (38”), PT¬mix 11”2 (10”9). Dosage of factor VII: 2.7%. Dosage of factor X: 102%. Diagnosis: congenital factor VII deficiency. Treatment: frozen plasma (15 ml/kg/day x 3 days) and provera 10 mg/dayx 4 days.

treatment of the idiopatic throbocytopenic purpera in children

From Feb 1997 to Feb 1998, 74 children with ITP, that diagnosed and treated for the first time (38 cas males, 36 cas females) at Centre of Blood Transfussion and Hematology, HCM City. Results of the treatment regimens corticosteroids 4mg/kg body weight/day and corticosteroids 2mg/kg body weight/day are noted: complete response (74.2%) partial response (9%), dependent of Corticosteroids (6.2%), persisstent thrombocytopenia (10.6%) and persistent ITP after 6 months (chronic ITP): 20.2%. With the treatment regimen 4mg/kg body weight/day, platelet counts increased to > 50.10 g/l in a median of 4+/- 0.85 days and the treatment regiment 2 mg/kg body weight/day, platelet counts incresed to > 50.10g/l in a median of 10+/- days (P< 0.001).