Effect of a compound recipe [medical plants] on serum insulin levels of alloxan induced diabetic rabbits

The present study was planned to observe the hypoglycaemic effect of the 'Compound recipe' a combination of traditional medicinal plants in normal and alloxan induced diabetes mellitus. This study was performed to study the possible role of indigenous medicinal plants in the regeneration of pancreatic beta-cells and in treatment of insulin dependent diabetes mellitus. The 'Compound recipe' was administered daily in doses of 400-mg/kg body weight to normal and alloxan induced diabetic rabbits for a period of 4 months. The blood glucose and serum insulin levels were estimated before and 1,2,3 and 4 months after the administration of the extract. The extract exerted a significant [p>0.05] hypoglycemic effect in alloxan diabetic rabbits. The hypoglycemic effect was not significant [p>0.05] in normal rabbits. The extract exerted a significant [p<0.05] increase in insulin levels in alloxan diabetic rabbits. The effect on insulin levels was not significant [p>0.05] in normal rabbits. The doses used did not show acute toxicity or result in behavioral changes. From this study it may be conclude that the Compound recipe causes an increase in serum insulin levels in alloxan induced diabetic rabbits possibly due to regeneration of pancreatic beta cells

Effect of ficus relegiosa on blood glucose and total lipid levels of normal and alloxan diabetic rabbits

The present study was planned to observe the hypoglycemic effect of the 'Ficus relegiosa', a traditional medicinal plant. This study was performed to study the possible role of indigenous medicinal plants in the treatment of Diabetes mellitus [type-2] Normal rabbits were divided into 5 groups [1-5] of six animals each. Group 1 served as control and received 15 ml of water only. Group 2 received tolbutamide 500-mg/Kg body weight. Group 3-5 received the extract of Ficus relegiosa dissolved in 15ml of water in doses of 200 mg/Kg, 250 mg/Kg and 300mg/Kg body weight respectively. The diabetic rabbits were also divided in 5 groups on the same pattern. The blood glucose and total lipid levels were estimated before and 1,2, 3 and 4 hours after the administration of the extract. The extract exerted a significant [P< 0.05] hypoglycemic effect in normal rabbits, which was however short lived. The hypoglycemic effect was not significant [P> 0.05] in alloxan treated rabbits. The extract had no significant effect [P> 0.05] on total lipid levels in normal as well as in alloxan-treated diabetic rabbits. The doses used did not show acute toxicity or result in behavioral changes. From this study it may be concluded that the extract acts by initiating the release of insulin by pancreatic beta cells of normal rabbits

Effect of Grewia asiatica and peganum harmala on blood glucose levels of normal and alloxan-diabetic rabbits

The alcoholic extracts of the stem of Grewia asiatica and seeds of Peganum harmala were administered in doses A 250 mg/kg, 300 mg/kg and 350 mg/kg body weight to normal and alloxan - diabetic rabbits. The blood glucam levels were estimated before and 2, 4, 6 and 8 hours after the administration of the extract. The extract of Grewia asiatica exerted a significant [P<0.05] hypoglycaemic effect in normal rabbits. The hypoglycaemic effect was nil significant [P>0.01] in alloxan-diabetic rabbits. The extract of Peganum harmala did not produce any significant [P>0.01] hypoglycaemic effect in normal as well as in alloxan-treated-diabetic rabbits. From this study it may 6e concluded that the extract of Grewia asiatica acts by initiating the release of insulin from pancreatic Beta cells d normal rabbits. Moreover, Peganum harmala, which is used as an anti-diabetic in folk medicine, did not show any hypoglycaemic effect in normal as well as in diabetic rabbits

Antidiabetic activity of indigenous plants

This study deals with the effects of alcoholic extracts of seven indigenous plants on blood glucose levels of normal and alloxan induced diabetic rabbits. The blood glucose levels were estimated before and 2, 4, 6 and 8 hours after the administration of a single oral dose [500 mg/kg] of each extract. The extracts of six plants did notproduce significant hypoglycaemic effect in normal or alloxan treated diabetic rabbits. except the extract of one plant, Ficus bengalensis which exerted a significant hypoglycaemic effect [P < 0.05] in both normal and alloxan induced diabetic u rabbits. From this study, it can be concluded that Ficus bengalensis can be effective in the control of diabetes mellitus at least in animel models. Study for human use and safety need to be carried out

Effect of Allium Cepa on blood Glucose levels of normal and Alloxan treated Diabetic rabbits

The aquous solution of dried powder of the Allium cepa was administered in doses of 100, 150 and 200 mg/kg body weight to normal and alloxan treated diabetic rabbits. The blood glucose levels were estimated before and 2,4,6 and 8 hours after the administration of the solution. The solution exerted a significant [P< 0.05] hypoglycaemic effect in both normal and diabetic rabbits. In normal rabbits, oral administration of 150 and 200 mg/kg doses caused decrease in blood glucose levels at 2,4,6 and 8 hours, while maximum decrease was at 6 hours. In the alloxan treated diabetic rabbits, 200 mg/kg dose only could produce significant decrease at 4,6 and 8 hours while maximum decrease was at 6 hours. The doses used did not show acute toxicity or behavioral changes. It may be concluded that the plant contains one or more hypolglycaemic principles which can reduce the blood glucose in normal rabbits and in those with alloxan induced diabetes

Pharmacological screening of some indigenous plants for anti-diabetic activity

This study deals with the effects of alcoholic extracts of seven indigenous plants on blood glucose levels of normal and alloxan-diabetic rabbits. The blood glucose levels were estimated before and 2,4,6 and 8 hours after the administration of a single 500 mg / kg oral dose. The extracts of six plants had no significant [P> 0.1] hypoglycaemic effect in normal as well as alloxan-diabetic rabbits. The extract of one plant i.e. Momordica Charantia, however, exerted a significant [P < 0.05] hypoglycaemic effect in both normal and alloxan diabetic rabbits. From this study this may be concluded that Momordica charantia can be effective in the control of diabetes mellitus

Anti-diabetic activity of indigenous plants

This study deals with the effects of alcoholic extracts of ten indigenous plants on blood glucose levels of normal and alloxan diabetic rabbits. The blood glucose levels were estimated before and 2, 4, 6 and 8 hours after the administration of a single oral dose [500mg/kg] of extract. The extracts of nine plants did not produce any significant hypoglycemic effect in normal or alloxan treated diabetic rabbits. However, the extract of one plant, Cuminum cyminum exerted a significant hypoglycemia effect [P < 0.05] in both normal and alloxan diabetic rabbits. From this study it may be concluded that Cuminum cyminum can be effective in the control of diabetes mellitus

Effects of acacia arabica and caralluma edulis on blood glucose levels of normal and alloxan diabetic rabbits

The powdered seeds of Acacia arabica and roots of Caralluma edulis were administered in doses of 2, 3 and 4 gm/kg body-weight to normal and ailoxan-diabetic rabbits. The blood glucose levels were estimated before and 2, 4, 6 and 8 hours after the administration of plant suspension. The powdered seeds of Acacia arabica exerted a significant [P <0.05] hypoglycemic effect in normal rabbits. The hypoglycemic effect was not significant [P >0.01] in alloxan diabetic rabbits. The powdered roots of Caraliuma edulis did not produce any significant [P >0.01] hypoglycaemic effect in normal as well as in alloxan diabetic rabbits. The doses used did not show any acute toxicity and behavioural changes. From this study it may be concluded that the powdered seeds of Acacia arabica act by initiating the release of insulin from pancreatic beta cells of normal rabbits. Moreover, Carallunria edulis did not show any hypoglycaemic effect in normal as well as in diabetic rabbit

Effect of Musa sapientum on blood glucose levels of normal and alloxan treated diabetic rabbits

The alcoholic extract of the flowers of Musa Sapientum was administered in doses of 10, 20, 30, mg/kg body weight to nonmetal and alloxan treated diabetic rabbits. The blood glucose levels were estimated before and 2, 4, 6 and 8 hours a after the administration of the extract. The extract exerted a significant [P<0.05] hypoglycaemic effect in normal rabbits. The hypoglycaemic effect was not significant [P>0.1] in alloxan treated rabbits. The doses used did not show acute toxicity or behavioral changes. It may be concluded that the extract acts by initiating the release of insulin from pancreatic beta cells of normal rabbits

Effect of eriobotrya japonica on blood glucose levels of normal and alloxan diabetic rabbits

The alcoholic extract of the leaves of Eriobotrya japonica was administered in doses of 100, 150 and 200 mg/kg body weight to normal and alloxan diabetic rabbits. The blood glucose levels were estimated before and 1, 2, 3 and 4 hours after the administration of the extract. The extract exerted a significant [P < 0.05] hypoglycaemic effect in normal rabbits which was however short-lived. The hypoglycaemic effect was not significant [P> 0.1] in alloxan-treated rabbits. The doses used did not show acute toxicity and behavioural changes. From this study, it may be concluded that the extract acts by initiating the release of insulin from pancreative beta cells of normal rabbits