Effect of Salicylate on DPOAEs and ABRs in Guinea Pigs / 대한이비인후과학회지

BACKGROUND AND OBJECTIVES: Salicylates are well-known for producing reversible hearing loss and tinnitus. However, the site and mechanism of salicylate ototoxicity remain unresolved. Recent experiments suggest that reversible biochemical and/or metabolic changes in the cochlea seem to play an important role in salicylate ototoxicity. The purpose of this study was to investigate the site of lesion in salicylate ototoxicity by audiometric study. MATERIALS AND METHOD: ABRs and DPOAEs were observed after intraperitoneal injection of 500 mg/kg of sodium salicylate on 24 ears of guinea pigs. RESULTS: Salicylate produced a significant increase in the ABR threshold. Maximum changes were obtained in 4 hours, and recovered to the baseline in 24 hours after salicylate administration. The pattern of hearing loss shown by latency-intensity function was compatible with the cochlear type of hearing loss. The echo amplitude on DPOAEs at f2=2002, 4004 Hz was significantly decreased at 2, 4, 6, 8 hours, and returned to the baseline in 24 hours after salicylate administration. The time course of the change of DPOAEs was parallel with that of ABRs. CONCLUSION: These results reflect that the cochlear outer hair cells may be the main site of lesion in salicylate ototoxicity.

A Case of Allergic Fungal Sinusitis / 대한이비인후과학회지

Since the initial description of allergic fungal sinusitis by Millar et al. in 1981, reported cases have been increasing. However, one case of allergic fungal sinusitis has been reported in Korea. The diagnosis can be established by demonstrating type I hypersensitivity reaction, nasal polyposis, characteristic CT scan, eosinophilic mucus without evidence of fungal invasion into sinus tissue, and a positive fungal stain or culture of sinus contents. The authors present a case which met the diagnostic criteria of allergic fungal sinusitis. This patient had nasal polyp and showed elevated level of total IgE, peripheral eosinophilia, positive MAST and strongly positive immediate skin reactivity to fungal antigens. On histologic examination, typical allergic mucin containing sheets of eosinophils, Charcot-Leyden crystals was found. Fungal hyphae were also found in the mucin content.

Effect of Panax Ginseng Saponin on Salicylate Ototoxicity in Guinea Pigs / 대한이비인후과학회지

BACKGROUND AND OBJECTIVES: Large doses or long-term use of salicylate may cause reversible tinnitus and hearing loss. The exact cause of salicylate ototoxicity in unknown. Decreased cochlear blood flow following reversible biochemical changes in the cochlea seems to play an important role in salicylate ototoxicity. Protopanaxatriol and protopanaxadiol saponin of the Panax ginseng are known to have a vasodilatory effect. We investigated the effect of Panax ginseng saponin on salicylate induced hearing loss in guinea pigs. MATERIALS AND METHODS: Guinea pigs were divided into two groups. The control group was injected with salicylate (300 mg/kg, IM) and the experimental group was pretreated with Panax ginseng saponin (100 mg/kg, IP) before salicylate injection. ABR threshold was measured hourly after salicylate injection. RESULTS: The control group showed a maximal hearing loss (20+/-3.54 dBnHL) in 3 hours after the salicylate injection. Comparing with the control group, the experimental group revealed a significantly different maximal hearing loss (5+/-3.54 dBnHL). CONCLUSION: These results suggest that the protopanaxatriol and protopanaxadiol saponin of the Panax ginseng can attenuate salicylate induced hearing loss.