ABSTRACT
Abstract Systemic amyloidosis secondary to psoriatic arthritis is rare, and published data are based mainly on case reports and are associated with increased mortality. This is the report of a patient with long-term psoriatic arthritis and chronic sialadenitis, who showed an inadequate response to therapy. The diagnosis of secondary amyloidosis was attained through biopsies of genital skin lesions. Although very rare, it is important that dermatologists and general practitioners consider the possibility of amyloidosis in patients with chronic inflammatory diseases, since an early intervention can be implemented, and thus, the prognosis of this condition can be improved.
Subject(s)
Humans , Psoriasis , Arthritis, Psoriatic/complications , Immunoglobulin Light-chain Amyloidosis , Amyloidosis/complications , Amyloidosis/diagnosis , SkinABSTRACT
Abstract Reactivation of chronic Trypanosoma cruzi infection in solid organ transplant recipients (SOTRs) has been reported. The patient presented with a 2-week history of two painful erythematous, infiltrated plaques with central ulceration and necrotic crust on the left thigh. She had a history of chronic indeterminate Chagas disease (CD) and had received a kidney transplant before 2 months. Skin biopsies revealed lobular panniculitis with intracellular amastigote forms of T. cruzi. The patient was diagnosed with CD reactivation. Treatment with benznidazole significantly improved her condition. CD reactivation should be suspected in SOTRs living in endemic areas with clinical polymorphism of skin lesions.
Subject(s)
Humans , Female , Trypanosoma cruzi , Panniculitis , Kidney Transplantation/adverse effects , Chagas Disease/diagnosis , ThighABSTRACT
Abstract: The oncogenic role of high-risk HPV in anogenital, head and neck, and cervical cancer is well recognized, but not in skin cancer in the general population. Some authors have demonstrated their appearance mainly on the hands and feet, particularly in the area of the nail bed, which could be due to contamination with HPV types from anogenital regions. Here, we describe a case of genital HPV associated with SCC on the nose tip in an immunocompetent young man, which was confirmed by histopathological findings and in situ hybridization. The importance of this report is to highlight the potential role of HPV in the etiology of skin cancer in an immunocompetent individual.
Subject(s)
Humans , Male , Middle Aged , Skin Neoplasms/virology , Carcinoma, Squamous Cell/virology , Nose Neoplasms/virology , Papillomavirus Infections/complications , Immunocompetence , Skin Neoplasms/immunology , Skin Neoplasms/pathology , Carcinoma, Squamous Cell/immunology , Carcinoma, Squamous Cell/pathology , Nose Neoplasms/immunology , Nose Neoplasms/pathology , Papillomavirus Infections/pathology , Genital Diseases, Male/pathology , Genital Diseases, Male/virologyABSTRACT
Abstract Phaeohyphomycosis is an infection caused by a filamentous fungus that contains pigment melanin in its cell wall. We report two cases caused by Exophiala sp. emphasizing the clinical variability of the disease, as well as diagnostic and therapeutic difficulties of this opportunistic infection in immunosuppressed patients (kidney transplant).
Subject(s)
Humans , Male , Middle Aged , Exophiala/isolation & purification , Kidney Transplantation/adverse effects , Phaeohyphomycosis/pathology , Antifungal Agents/therapeutic use , Immunocompromised Host , Immunosuppressive Agents/adverse effects , Opportunistic Infections/immunology , Opportunistic Infections/pathology , Opportunistic Infections/therapy , Phaeohyphomycosis/immunology , Phaeohyphomycosis/therapy , Skin/pathologyABSTRACT
A epidermodisplasia verruciforme (EV) é genodermatose rara, caracterizada por infecção disseminada por tipos específicos de vírus papiloma humano (HPV), desenvolvimento de tumores cutâneos malignos e distúrbios imunológicos.Correlacionar aspectos clínicos em 13 doentes com EV, na tentativa de contribuir para melhor conhecimento da enfermidade. Avaliação clínica de 13 doentes com EV durante o período de três anos. O diagnóstico clínico foi confirmado pelo exame histopatológico e imuno-histoquímico.A EV teve início na infância com lesões de verruga plana-símile e/ou máculas eritematosa na face e região cervical. A consangüinidade foi observada na maioria dos doentes (12/13). Clinicamente, o polimorfismo das lesões foi intenso, caracterizado por lesões de verruga plana-símile, pitiríase versicolor-símile, máculas eritematosas e lesões de queratose seborréica-símile. A transformação maligna das lesões foi observada em oito doentes (62 por cento). O crescimento tumoral provocou perda tecidual importante em 50 por cento dos casos, e em 25 por cento foi registrado óbito pelas metástases. A EV apresenta alta incidência familiar e provável transmissão autossômica recessiva. O intenso polimorfismo clínico das lesões não afeta o couro cabeludo e mucosas. A apresentação clínica ômalignaö foi a mais freqüente (62 por cento), seguida pela ôbenignaö (23 por cento) e ômistaö (15 por cento). Os tumores cutâneos malignos são freqüentes, múltiplos, destrutivos, geram metástases e provocam morte