ABSTRACT
Introduction: Parkinson’s disease (PD) is one of the chronicneurodegenerative disorder and is the most common cause ofparkinsonism, which is a syndrome manifested by rest tremor,rigidity, bradykinesia, and postural instability. Diabeteswhether is a risk factor for developing PD is a question oftenraised for many years and to date there are conflicting data onassociation of diabetes and Parkinson’s disease. Study aimedto study the effect of glycemic status on Idiopathic Parkinson’sdisease (PD) and to identify the modifiable and non modifiablerisk factors in idiopathic Parkinson’s disease (PD).Material and methods: Consecutive patients with adiagnosis of idiopathic parkinson’s disease(PD) satisfyingUK Parkinson’s disease society brain bank clinical diagnosticcriteria attending the department of neurology during theperiod January 2019 to December 2019 were included in thestudy. Study design was a cross sectional, observational study.Results: Total of 70 patients were enrolled in the study. Tremorwas the most common motor symptom. 53.3% of subjects hadone or the other non motor symptoms. Diabetes was presentin 38.6% of subjects. Mean FBS among the cases was 112.36% of the subjects had poor control of diabetes based ontheir HbA1C values (HbA1C >7). There was statisticallysignificant relation between glycemic control and clinicalstage of PD with a P value <0.05.Conclusion: Prevalence of diabetes in PD is significantlyhigher compared to general population statistics. PD patientshad favourable lipid parameters. Poor glycemic control amongPD with diabetes had statistically significant relationship withclinical stage.
ABSTRACT
Introduction: Large territory middle cerebral artery strokesare devastating events that result in high rates of disabilityand death. Nearly half of all stroke survivors never regainfunctional independence. Current research aimed to study theclinical profile and risk factors of massive middle cerebralartery (MCA) infarction and to study the relation of alcoholismand its pattern to massive MCA stroke.Material and methods: Patients admitted with massive MCAinfarct with an early ischemic change on CT affecting at least>50% of the MCA territory within 48 hours of symptom onsetwere included in the study. Stroke mimics and those withhistory of previous stroke were excluded. Study design was across sectional, observational study.Results: A total of 60 cases were analyzed. Mean age was55.4. 35% subjects had NIHSS >20.Diabetes was present in18. Total of 60% were alcoholics, and 83% of males werealcoholics.31 subjects were heavy drinkers. Binge drinkingwas present in 30%.Mean duration of alcohol was 9.5 years.Average intake per day was 120 ml. Mean ASPECT scorein the subjects was 3. 25 patients had a MRS 4 at discharge.Craniotomy done in 6 cases. Total death were 17(29%).Aspiration pneumonia was the common cause of death (5).Conclusion: NIHSS 20 or more was associated with adverseoutcome (P value <0.05).60% were alcoholics. Binge intake in30%(associated with adverse outcome P value <0.05). MeanAspect score was 3 (3 or less associated with adverse outcomeP value <0.05).