ABSTRACT
Objective@#The aim of this study was to update the epidemic situation of dengue fever (DF) and provide new insights for the consideration of disease control in Fujian province, China.@*Methods@#Details about DF cases in Fujian reported during 2004-2017 were collected and analyzed. The envelope (E) genes of isolates of dengue virus (DENV) were sequenced for phylogenetic analysis.@*Results@#The number of imported DF cases had increased dramatically since 2013, and the source regions expanded from Southeast Asia to South Asia, America, Oceania, and Africa, as well as the surrounding provinces. This resulted in local outbreaks and indigenous cases of DF that occurred more frequently, with 10 of 13 local outbreaks and 85.9% (1,252/1,458) of indigenous cases reported in 2013-2017. Compared with only two coastal cities before 2013, four coastal and one inland city in 2013-2017 experienced the local DF outbreaks. The phylogenetic analysis of E genes confirmed that the import of DENV, not only from abroad but also from the surrounding provinces, played an important role in dissemination and local outbreaks of DF in Fujian.@*Conclusions@#The frequent import of DF cases from not only abroad but also the surrounding provinces resulted in increased incidence, frequent local outbreaks, and expansion of distribution in Fujian in recent years. There is a need for urgent measures to improve disease control in this province.
ABSTRACT
Objective To analyze the effect of Taohong-Siwu decoction combined with percutaneous vertebroplasty on elderly patients with osteoporotic vertebral compression fractures. Methods A total of 60 elderly patients with osteoporotic vertebral compression fractures, from March 2015 to March 2017, were randomly divided into two groups(30 patients in each group). The patients in the control group were treated with percutaneous vertebroplasty, and the patinets in the study group received Taohong-Siwu decoction combined with percutaneous vertebroplasty. Before treatment and at 4 weeks after treatment, the ODI scores, VAS scores were recorded, and the inflammatory reaction (TNF-α, IL-6) and bone metabolism (ALP, BGP) were compared between two groups. Results The scores of ODI (21.1 ± 1.7 vs. 22.5 ± 1.9, t=3.111) and VAS scores (1.2 ± 0.7 vs. 1.6 ± 0.8, t=2.101) in the study group were significantly lower than those in the control group (P<0.05). The TNF-α (367.67 ± 87.11 vs. 415.93 ± 72.62 ng/L, t=2.331) and IL-6 (71.47 ± 16.83 vs. 81.43 ± 17.24 mg/L, t=2.266) in the study group were significantly lower than those in the control group (P<0.05). The ALP (70.27 ± 7.96 vs. 65.77 ± 8.45 U/L, t=2.123) and BGP (10.29 ± 2.37 vs. 9.01 ± 2.23 g/L, t=2.127) in the study group weresignidicantly higher than those in the control group (P<0.05). Conclusions The Taohong-Siwu decoction could relieve the pain, improve the function of daily life, relieve the inflammatory reaction and increase the level of ALP and BGP in the elderly patients with osteoporotic vertebral compression fractures.