ABSTRACT
Objective To explore the various risk factors of the Stanford type B aortic dissection(ADA) patients in perioperation period .Methods Data of 100 Stanford type B ADA patients was collected from June 2009 to June 2012 in our hospital ,and their clinical characteristics and risk factors were analyzed .Results The clinical features of patients with ADA were related to many fac‐tors .Logistic regression analysis showed that the death risk of female was 4 .5 times larger than the male .Diastolic pressure was an independent protective factor of prognosis ,and 1 mm Hg increase in diastolic pressure resulted in 6% mortality decrease . Conclusion The clinical features of patients with ADA is related to many factors ,among which the gender is an independent one;level of diastolic blood pressure is independent protective factor of prognosis .
ABSTRACT
Objective To investigate synergistic effect of Huang Lian Jie Du decoction (HLT) on sodium valproate(SVA) in epi-leptic rats by epileptic rats induced by lithium chloride-pilocarpine .Methods Epileptic rats were induced by intraperitoneal injection of lithium chloride and pilocarpine .The synergistic anti-epilepsy effect of HLT and SVA was investigated .The level of ALT ,AST , SVA in serum ,GSH-Px and MDA were determined at the end of a 4 week adminstration .Then the ultrastructure alteration of the liver were also observed by transmission electon microscope .Results The adminstration of SVA together with HLT can reduce be-havior of epileptic rats .Significant decrease in the level of ALT ,AST ,and SVA in serum of rats and noticeable increases in the ac-tivity of GSH-Px were observed in the co-administered groups compared with administere SVA alone group(P<0 .01) .At the same time ,light microscopic study indicates rats in co-administered SVA and high-dose HLT group has intacthepatic histology .Conclu-sion HLT could has synergistic anti-epileptic effect and relieve the hepatotoxoicity of SVA when co-administered .