ABSTRACT
Choroidal osteoma is an unusual form of intraocular calcification seen in otherwise healthy eyes. It is a benign idiopathic osseous tumor of the choroid, typically seen in young females. Choroidal neovascular membrane (CNVM) is a complication seen in one-third of these patients and carries a poor visual outcome. We report a case of a 25-year-old hyperthyroid female with choroidal osteoma and subfoveal CNVM in her left eye which was successfully treated using low-fluence photodynamic therapy (PDT) with verteporfin followed by a single injection of intravitreal ranibizumab.
Subject(s)
Adult , ANTIBODIES, MONOCLONAL, HUMANIZED ADMINISTRATION & , Bone Neoplasms/complications , Bone Neoplasms/diagnosis , Bone Neoplasms/drug therapy , Choroid Neoplasms/complications , Choroid Neoplasms/diagnosis , Choroid Neoplasms/drug therapy , Choroidal Neovascularization/diagnosis , Choroidal Neovascularization/drug therapy , Choroidal Neovascularization/etiology , Diagnosis, Differential , Female , Follow-Up Studies , Humans , Intravitreal Injections , Microscopy, Acoustic , Osteoma/complications , Osteoma/diagnosis , Osteoma/drug therapy , Photochemotherapy/methods , Tomography, Optical Coherence , Visual AcuityABSTRACT
Angioid streaks also called Knapp striae are small breaks in the Bruch's membrane and have been reported with a host of systemic diseases. Rupture of streaks or development of secondary choroidal neovascular membrane (CNVM) carries a dismal visual prognosis. We report the successful treatment of CNVM secondary to Paget's disease using low fluence photodynamic therapy (PDT) and intravitreal ranibizumab.