ABSTRACT
PURPOSE: To establish the strength of the association between routine tear function tests and conjunctival impression cytology (CIC) and to determine whether they simulate the morphological and cytological changes that occur on the ocular surface in dry eye. What are the sensitivity, specificity and positive predictive values of these tests when CIC is considered the gold standard? METHODS: The tear film profile included tear film break up time (TBUT), Schirmer's-1, Rose Bengal scores (RBS), and impression cytology. CIC samples were obtained from the inferior bulbar conjunctiva and stained with periodic acid-Schiff and counter stained with hematoxylin and eosin. RESULTS: The mean Schirmer's value was 11.66 +/- 5.90 in patients and 17.17 +/- 2.97 in controls (p Schirmer's > RBS, and the specificity was Schirmer's > TBUT > RBS in decreasing order when CIC was considered the gold standard.
Subject(s)
Adolescent , Adult , Child , Female , Humans , Male , Middle Aged , Young Adult , Case-Control Studies , Conjunctiva/pathology , Diagnostic Techniques, Ophthalmological/standards , Dry Eye Syndromes/diagnosis , Eosine Yellowish-(YS) , Goblet Cells/pathology , Hematoxylin , Ophthalmology/standards , Periodic Acid-Schiff Reaction/standards , Predictive Value of Tests , Rose Bengal , Sensitivity and Specificity , TearsABSTRACT
The purpose of this study is to evaluate the outcome of manual small incision cataract surgery [SICS] in eyes with uveitic cataract. Setting- Medical college hospital of the subcontinent, Retrospective case series. In this retrospective study, patients who underwent SICS with posterior chamber intraocular lens implantation for uveitic cataract from 2006 to 2009 were evaluated. Patients with less than 3 months follow-up were excluded. Post-operative vision and complications were analyzed. A total of 54 patients completed the study. The mean age was 52.3 +/- 9.3 years. The mean follow-up was 11.53 +/- 5.05 months. The mean surgical time was [10.2 +/- 3.8 min]. Etiological diagnosis was possible in 31.41% [17/54] of patients. There was a statistically significant improvement in vision after surgery [P< 0.00l]. When uveitis was well-controlled, pre-operative corticosteroids did not change post-operative inflammation [P= 0.796]. However, pre-operative corticosteroids were statistically significantly associated to final best corrected visual acuity [BCVA] [P = 0.010]. SICS with posterior chamber intraocular lens implantation is safe in most cataracts due to uveitis and improves BCVA at 6 months. Inflammation should be well-controlled pre-operatively for at least 3 months. Posterior capsule opacification, macular edema and persistent uveitis were the main factors affecting visual outcome. SICS requires minimal instrumentation, surgical time is short and can also be performed in rural clinics and eye-camps, where phacoemulsification machines are unavailable. SICS may be a more practical and cost-effective technique for uveitic cataract, in such circumstances