ABSTRACT
The effectiveness of three antituberculosis regimens were evaluated and compared on 175 patients with active pulmonry tuberculosis. Patients were assigned to one of three treatment regimens according to a randomized schedule of 1-Nine months regimen; initial two months of [2RHSRH7] Rifaimpicin 0.45 g/d-0.6 gm/d + isoniazid 0.3 gm/d + streptomyein 0.75 gmd-l gm/d. Continuation phase seven months of: Rifampiein 0.45 gm/d-0.6 gm/d + isoniazid 0.3 gm/d. 2-Six months regimen: [2RH-ISZ/RH4]; initial two months of: Rifampicin 0.45 gm/d-0.6 gm/d + isoniazid 0.3 gm/d + streptomycin 0.75 gm/d-I gm/d ' pyrazinaminde 1.5 gm/d-2 gm/d. Continuation phase four months of: Rifampicin 0.45 gm/d-0.6 gm/d + isoniazid 0.3 gm/d. 3 months regimen [2RHZIRH4]; initial phase two months of: Rifampicin 0.45 gm/d-0.6 gu + isoniazid 0.3 gm/cl + streptomycin 0.75 g gm/d + pyrazinaminde 1.5 gmld-2 guild. Continuation phase four months of: Rifampiein 0.45 gmfd-0.6 guild + isoniazid 0.3 gm/d. 118 patients completed the course of treatment, 7 patients defaulted, 4 patients were excluded because they could not tolerate the effects of side effects of drugs, and 6 patients remained bacillary exceretors i.e. became chronic cases. All these regimens produced significant effectiveness [P<0.05], but the second regimens [2RHSZ/RHI4] is the most highly effective than the other two regimens [P< 0.05]