ABSTRACT
Objective:To investigate the effect of TNP-470 on the vasculogenic mimicry in gastric cancer cell line SGC-7901 in vitro.Methods:Cultured SGC-7901 cells were devided into TNP-470 group and control group.The effect of proliferation,invasion and tube formation on SGC-7901 cells were detected by colone formation assay,invasion assay and tube formation assay respectively in vitro.Results:Number of colone formation of TNP-470 group was not significantly lower than the control group(P0.05),the number of cells which crossed to the lower surface of the matrigel-coated filters in TNP-470 group was significantly lower than the control group(P0.01).Tube formation could be inhibited by TNP-470.Conclusion:TNP-470 can inhibit the vasculogenic mimicry formation of gastric cancer cell line SGC-7901 in vitro.