The effect of ?-amyloid protein on the behaviors and SOD activity and MDA content of hippocampus in D-galactose-induced aging rats / 中国病理生理杂志

AIM: To study the effect of ?-amyloid protein (?-AP) and D-galactose(D-gal) on learning-memory and SOD activity and MDA content of hippocampus in rats. METHODS: The behaviors of rats were measured by using open field, Y-maze and one-trial passive avoidance response, and the content of SOD and MDA were measured. RESULTS: In the D-gal and D-gal+?-AP group rats, the spontaneous activities and responses to novel environment in the open field were significantly decreased, and the abilities of learning-memory were remarkably attenuated, the content of SOD decreased and MDA content increased markedly in hippocampus (P

Effect of ?-amyloid protein on the fluidity of mitochondrial membrane in hippocampus of aging rats induced by D-galactose / 中国病理生理杂志

AIM: To study the effect of ?-amyloid protein (?-AP) on the fluidity of mitochondrial membrance in hippocampus of the aging model of rats.METHODS: Based upon the model of aging rats induced by D-galactose (D-gal) and hippocampal microinfusion of ?-AP, the behaviors of rats were observed. Using DPH as fluorescent probe, the viscous cofficient (?) of mitochondrial membrane was determined, and Na +-K +ATPase activity was measured.RESULTS: In the D-gal+?-AP group rats, Na +-K +ATPase activity was lower than D-gal and ?-AP groups ( P