ABSTRACT
OBJECTIVE:To compare the efficacy of lobaplatin/ cisplatin combined with etoposide in the treatment of primary small cell lung cancer. METHODS:60 patients with small cell lung cancer were randomly divided into observation group and con-trol group. Observation group was given 30 mg/m2 Lobaplatin injection,adding into 500 ml 5% Glucose injection,d1,by intrave-nous infusion for 1 h+100 mg/m2 Etoposide injection,adding into 500 ml 0.9%Sodium chloride injection,d1-3,by intravenous infu-sion for 1 h. Control group was given 25 mg/m2 Cisplatin injection,adding into 500 ml 0.9% Sodium chloride injection,d1-3,by in-travenous infusion for 1 h+Etoposide injection(the same dose with observation group). 3-week was regarded as a chemotherapy cy-cle. The clinical efficacy and toxicities in 2 groups were observed. RESULTS:There were more than 2 cycles for both groups. There was no significant difference in the total effective rate between 2 groups(P>0.05),and the incidences of nausea,vomiting and diarrhea in observation group were significantly lower than control group,the differences were statistically significant (P<0.05). CONCLUSIONS:Lobaplatin/ cisplatin combined with etoposide has similar efficacy in the treatment of primary small cell lung cancer,and lobaplatin has better safety.
ABSTRACT
ObjectiveTo explore the clinical effect of transcatheter hepatic arterial chemoembolization and systemic chemotherapy on colorectal cancer with hepatic metastasis.Methods50 cases of colon cancer with hepatic metastasis according to treatment methods were divided into A,B group.A group treated by TACE plus intravenous chemotherapy,B group treated by intravenous chemotherapy alone.Side effects,changes in liver tumor size and survival rate were observed.ResultsThe incidence of side effects of two groups had no significant difference ( P ＞ 0.05 ).A group of liver lesions smaller in size or stable is more than in group B( P ＜0.05 ).A group of 1 year,3 years survival rate is 84％and 64％respectively,which is higher than B group 56％and 36％ ( all P ＜ 0.05 ).ConclusionTranscatheter hepatic arterial chemoembolization and systemic chemotherapy is a safe and effective treatment of colon cancer with hepatic metastasis,it can obviously raise the survival rate.
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Objective To analyze the effect and safety of interventional therapy by trans uterine artery for treatment of tubal pregnancy. Methods Forty-two patients with tubal pregnancy were performed two side uterine arteries. MTX perfusion and embolization with gelfoam particles guided by DSA fluoroscopy. Results Forty patients obtained the decline of serum β-HCG value and 39 patients' ectopic mass absorption after treatment. Two patients occurred ectopic mass bleeding after interventional therapy and emergency surgical operation were done, but the amount of bleeding was low than 400ml. Conclusion Interventional therapy by trans uterine artery for treatment of tubal pregnancy could preserve the function of fallopian tubal, it was more benefit for patients who want normal pregnancy.