ABSTRACT
This article was aimed to analyze and summarize the historical origin, chemical constituents, pharmacological effects, clinical research and standardization research on Digeda-4 Flavored Decoction, in order to provide references for further study on Mongolian medicine and application. The historical origin, chemical constituents, pharmacological effects, clinical application and standardization research on Digeda-4 Flavored Decoction were analyzed and summarized through literature searching. It put forward the existing prescription problems and further research ideas. The results showed that Digeda-4 Flavored Decoction was a common Mongolian preparation. It had a long history with certain studies on its chemical constituents and pharmacological action of single herb. However, the research on compound prescription was still relatively backward. Studies on quality controlled standards, pharmacology, pharmacodynamics and toxicology studies were lacked of. The standardization, high speed, informationization were the future direction and trend of development. It was concluded that Digeda-4 Flavored Decoction was commonly used in Mongolian medicine. It was hoped to lay a solid foundation for its standardization research, pharmacological research, and standard clinical study in the future to develop Digeda-4 Flavored Decoction with stable quality, reliable curative effect, less toxic side effect, and convenient administration.
ABSTRACT
Objective To study the effect of Mongolian medicine Senden decoction on IFN-γexpression of CIA model rats.Methods 10 rats were randomly selected as the normal group.The other 50 SD rats were established CIA model,and were randomly divided into 5 groups:the model group,Mongolian medicine morito decoction of high, medium and low dose group,tripterygium glycosides group.At different time points,the arthritis index,immunohisto-chemical expression of IFN-γwere detected in the synovial cytokine,the protein expression of IFN-γin jaw joint was detected by Western blot.Results Mongolian Senden decoction could improve CIA rat arthritis index,improve the IFN-γpositive expression in synovial joints, reduce the expression of IFN -γprotein in the claw gamma, tripterygium wilfordii group and Mongolian senden decoction high dose group improved the most obviously,and there was significant difference compared with model group(FAI 40d=27.276,FIFN-γPositive =32.654,FIFN-γprotein =674.124, all P=0.000).Conclusion Mongolian medicine Senden decoction can improve symptoms and IFN-γjoint inflam-matory cytokine expression in rat CIA model,the effect of joint synovial membrane,and the positive control medicine tripterygium glycosides, but there is a dose -response relationship, and low doses of Mongolian medicine senden decoction high dose effect is better than that of medium and low dose.
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the expression of orotate phosphoribosyltransferase (OPRT) in colorectal carcinoma and analyze its correlations with the toxicities of chemotherapy.</p><p><b>METHODS</b>The expression of OPRT mRNA was detected using RT-PCR in colorectal carcinoma tissues and paired adjacent normal tissues from 58 patients receiving FOLFOX6 regimen chemotherapy. The toxicities of the chemotherapy were recorded, and the correlations between OPRT mRNA expression and the toxicities were analyzed.</p><p><b>RESULTS</b>OPRT mRNA expression was significantly higher in the tumor tissues than in the corresponding normal tissues (P=0.001), but OPRT expression in the tumor tissues was not correlated with the toxicities of the chemotherapy (P>0.05). OPRT level in the normal tissues showed a significant positive correlation with the occurrence of diarrhea in these cases (P=0.013).</p><p><b>CONCLUSION</b>OPRT expression in colorectal carcinoma tissues is not correlated with the toxicities of 5-FU-based regimen, but OPRT expression in the normal tissues can help predict the toxicities associated with 5-FU.</p>
Subject(s)
Adult , Aged , Female , Humans , Male , Middle Aged , Antimetabolites, Antineoplastic , Therapeutic Uses , Toxicity , Colorectal Neoplasms , Drug Therapy , Metabolism , Pathology , Fluorouracil , Therapeutic Uses , Toxicity , Intestinal Mucosa , Metabolism , Pathology , Orotate Phosphoribosyltransferase , MetabolismABSTRACT
0.05). Only the sVCAM-1 level of PILL type had significant difference with the healthy control group and KDDC type (P