Comparison of outcome of assisted reproductive methods in patient with polycystic ovaries syndrome and tubal factor

Polycystic ovaries syndrome [PCOS] is the most common endocrine disorder in infertile women with unovulatory cycle. This disorder is associated with abnormal circulating hormones but its effect on early embryonic development and pregnancy rate is unknown. The aim of this study was to compared the fertilization rate, embryo quality and pregnancy rate between 130 patients with polycystic ovary syndrome and 130 women with tubal factor for infertility and normal ovaries. One-hundred and thirty women with PCOS and 130 women with tubal infertility underwent Invitro fertilization [IVF] and Intracytoplasmic sperm injection [ICSI] treatments in Isfahan infertility center. Number of oocyte and embryo, fertility rate and embryo quality were compared between the two groups. Our results showed that average of oocyte retrieved, produced embryos and cumulative embryo quality score were higher in PCOS patients than in the tubal factor group. However, the fertilization rate was not different between the two groups [p<0.05]. The clinical pregnancy rate in PCOS patients was higher than the tubal factor group [p<0.05]. The probability of pregnancy in patients with PCOS is higher than patients with tubal factor. This is mainly due to selection of an embryo with high potential of earning and development

[ effect of polycystic ovaries syndrome on outcome of assisted reproductive technology in Isfahan Infertility Center-2003]

Polycystic ovaries syndrome [PCOS] is a very common endocrine disorder in infertile women with unovulatory cycle. This disorder is associated with abnormal circulating hormones. The response of ovaries to induction of ovulation is a contraversial issue and can have different results. This study tried to comapre the results of induction for ovulation in 130 patients who had polycystic ovary syndrome with that of 130 women who had tubal factor for infertility and had normal ovaries. In this prospective study, there were 260 women having PCOS and tubal infertility, undergoing Invitro Fertilization [IVE] and Intracytoplasmic Sperm Injection [ICSI] treatment in Isfahan infertility center. The number of oocyte. concentration of testosterone and andrestandion, fertility rate and embryo quality were compared. The findings showed that the mean of oocyte retrieved [13.1 versus 8.04], concentration of andrestandion in follicular and LH0 and testosterone in LH0 phase were higher in PCOS patients. The fertilization rate in PCOS patients [64%] showed no difference with tubal factor [67%]. The findings showed that the induction for ovulation in PCOS is followed by increasing serum androgen concentration through its effect on early embryonic development but due to high number of oocyts and embryo in PCOS patients versus patients with normal ovaries, the chance of more embryos with ideal quality is increased by number of oocytes and subsequently embryos earned by IVF/ICSI technique