ABSTRACT
For several years it was believed that angiotensin II (Ang II) alone mediated the effects of the renin-angiotensin system. However, it has been observed that other peptides of this system, such as angiotensin-(1-7) (Ang-(1-7)), present biological activity. The effect of Ang II and Ang-(1-7) on renal sodium excretion has been associated, at least in part, with modulation of proximal tubule sodium reabsorption. In the present review, we discuss the evidence for the involvement of Na+-ATPase, called the second sodium pump, as a target for the actions of these compounds in the regulation of proximal tubule sodium reabsorption
Subject(s)
Animals , Angiotensin II/physiology , Angiotensin I/physiology , Extracellular Space/enzymology , Kidney Tubules, Proximal/enzymology , Sodium-Potassium-Exchanging ATPase/metabolism , Sodium/urine , Extracellular Space/physiology , Receptors, Angiotensin/physiologyABSTRACT
Descrevemos o isolamento do C. diphtheriae em uma regiäo endêmica da leishmaniose cutâneo-mucosa por Leishmania braziliensis braziliensis. Materiais das lesöes cutâneas foram obtidos de dezesseis pacientes. Nove deles foram portadores do bacilo (56%). Os microrganismos suspeitos foram identificados pelos testes de fluorescência sob luz ultravioleta, teste de virulência "in vitro" (por imunodifusäo radial simples), pesquisa da enzima pirazina-carboxilamidase (Pyz) e por imunofluorescência direta e indireta
Subject(s)
Humans , Corynebacterium diphtheriae/isolation & purification , Leishmaniasis, Mucocutaneous/microbiologyABSTRACT
O teste de fluorescencia pode ser usado para identificar bacilos diftericos toxinogenicos ou nao, alem de evitar esforco adicional, no processo de identificacao de microrganismos corineformes, nao fluorescentes, semelhantes ao C. diphtheriae. O teste da pirazina-carboxilamidase, uma vez que pode ser realizado em duas horas, mostra-se tambem de grande valor para o diagnostico laboratorial