ABSTRACT
Superoxide dismutase, ascorbic acid, glutathione and uric acid levels were decreased and xanthine oxidase, glutathione-s-transferase activities were increased in alcohol treated (2 g/kg body weight, once daily for 30 days) group. However, treatment with ethanolic extract of ginger (100 mg/kg, 200 mg/kg body weight, po, once daily for 30 days) these parameters came to normalcy showing the antioxidant effect of ginger. The antioxidant compounds of ginger may modulate the oxidative stress parameters. The biochemical findings were supplemented by histopathological examination of the kidney. Severe congestion and degenerative changes in tubules in alcohol treated rats were restored by ginger extract treatment. The results confirm the renal protective effect of ginger in alcohol treated rats.
ABSTRACT
This study was conducted to know the influence of alcohol and aging on carbohydrate metabolic profiles in the kidney tissue of control and experimental male albino rats. Alcohol significantly decreased the levels of glucose, total proteins, total carbohydrates and increased free amino acids, pyruvate and lactate in the kidney tissue of both age groups of rats. Aging induced the elevation of the levels of glucose, total carbohydrates, free amino acids and lactate, while it decreased the total protein and pyruvate contents. This suggests rapid utilisation of carbohydrates and degradation of proteins to meet energy demands under alcoholic stress. Thus more alterations were observed in the carbohydrate metabolic profiles in kidney of both age groups of experimental rats.