ABSTRACT
<p><b>OBJECTIVE</b>To investigate the clinicopathological characteristics of sporadic renal hemangioblastoma.</p><p><b>METHODS</b>Two cases of sporadic renal hemangioblastoma were studied by histological and immunohistochemical staining, along with review of the literature.</p><p><b>RESULTS</b>Both cases were presented with a renal mass during annual physical examination with an age of 40 and 45 years, respectively. The lesions located in the middle portion of the kidney with a sharp tumor border. Histopathologically, the tumors were characterized by two major components: capillary and stromal cells. Immunohistochemically, the stromal cells were positive for vimentin, NSE, S-100 protein and inhibin-α, and negative for CK, HMB45, Melan A, EMA, CD56 and syn. Both tumors showed a very low level of Ki-67 labeling. The endothelial cells were positive for CD34.</p><p><b>CONCLUSION</b>Sporadic renal hemangioblastoma is a rare benign neoplasm, the diagnosis of which is based on the characteristic follicular architecture and an exclusion of other carcinomas of the kidney.</p>