ABSTRACT
Polymorphisms of DNA repair genes, X-ray repair cross-complementing group 1 (XRCC1) might contribute to individual susceptibility to different types of cancers. We analyzed the relationship between XRCC1 polymorphisms and the risk of papillary thyroid carcinoma in a Korean sample. A hospital-based case-control study was performed in 111 papillary thyroid carcinoma patients and 100 normal control subjects. XRCC1 Arg194Trp and Arg399Gln single nucleotide polymorphisms (SNPs) were genotyped by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). The XRCC1 Arg194Trp Arg/Trp genotype was significantly associated with a decreased risk of papillary thyroid carcinoma compared to that of Arg/Arg genotype (odds ratio [95% confidence intervals]; 0.550 [0.308-0.983]). There was no significant association between XRCC1 Arg399Gln genotypes and risk of papillary thyroid carcinoma. Based on these results, the XRCC1 Arg194Trp Arg/Trp genotype could be used as a useful molecular biomarker to predict genetic susceptibility for papillary thyroid carcinoma in Koreans.
Subject(s)
Adolescent , Adult , Aged , Aged, 80 and over , Female , Humans , Male , Middle Aged , Amino Acid Substitution , Asian People/genetics , Case-Control Studies , DNA-Binding Proteins/genetics , Genetic Predisposition to Disease , Genotype , Odds Ratio , Polymorphism, Single Nucleotide , Republic of Korea , Risk Factors , Thyroid Neoplasms/geneticsABSTRACT
BACKGROUND AND OBJECTIVES: Radicular cysts, the most frequent cyst of the teeth bearing areas, occur commonly in the premaxillary region of young and middle aged persons. The lesion is usually silent, but large radicular cyst, especially in the maxilla, can make various symptoms and signs. The purpose of this study was to investigate the clinical characteristics and proper treatment of the radicular cyst in the maxilla. SUBJECTS AND METHOD: Ten radicular cysts in the maxilla, which were diagnosed and surgically treated between January, 2004 and June, 2006 at the Department of Otolaryngology, were included for this retrospective study. Clinical variables such as sex, age, frequency, symptoms, site of occurrence, histopathology, treatment and results of surgery were analyzed. RESULTS: From incisor to canaine, about 62.1% of the radicular cyst occurred around pre-maxillary region. The average age was 34.1 years and the most commonly occurring age fell between 20 and 30 years old. The most common symptoms were facial swelling or mass. All patients had preoperative dental check-up, and underwent root canal therapies in seven cases and dental extraction in one case. Complete enucleation was performed in all patients by Caldwell-Luc approach, sublabial approach and trans-palatal approach. CONCLUSION: Root canal therapy and complete surgical enucleation were both effective treatment methods for radicular cyst.