Limited-sampling strategy models for estimating the pharmacokinetic parameters of 4-methylaminoantipyrine, an active metabolite of dipyrone

Bioanalytical data from a bioequivalence study were used to develop limited-sampling strategy (LSS) models for estimating the area under the plasma concentration versus time curve (AUC) and the peak plasma concentration (Cmax) of 4-methylaminoantipyrine (MAA), an active metabolite of dipyrone. Twelve healthy adult male volunteers received single 600 mg oral doses of dipyrone in two formulations at a 7-day interval in a randomized, crossover protocol. Plasma concentrations of MAA (N = 336), measured by HPLC, were used to develop LSS models. Linear regression analysis and a "jack-knife" validation procedure revealed that the AUC0- and the Cmax of MAA can be accurately predicted (R²>0.95, bias <1.5 percent, precision between 3.1 and 8.3 percent) by LSS models based on two sampling times. Validation tests indicate that the most informative 2-point LSS models developed for one formulation provide good estimates (R²>0.85) of the AUC (0-infinity) or Cmax for the other formulation. LSS models based on three sampling points (1.5, 4 and 24 h), but using different coefficients for AUC(0-infinity) and Cmax, predicted the individual values of both parameters for the enrolled volunteers (R²>0.88, bias = -0.65 and -0.37 percent, precision = 4.3 and 7.4 percent) as well as for plasma concentration data sets generated by simulation (R²>0.88, bias = -1.9 and 8.5 percent, precision = 5.2 and 8.7 percent). Bioequivalence assessment of the dipyrone formulations based on the 90 percent confidence interval of log-transformed AUC(0-infinity) and Cmax provided similar results when either the best-estimated or the LSS-derived metrics were used

Crohn's disease with exclusive gastric involvement: a case report and review of the literature.

E relatado o caso de um paciente com doenca de Crohn com envolvimento exclusivamente gastrico. As queixas principais do paciente eram vomitos, epigastralgia e perda de peso ha tres meses. As avaliacoes clinica, radiologica e da endoscopia com biopsia sugeriam rinite plastica. Com o diagnostico de cancer gastrico o paciente foi submetido a gastrectomia total.O estudo histopatologico do estomago revelou granulomas e celulas gigantes, foi feito o diagnostico de doenca de Crohn.Evoluiu bem no pos operatorio com melhora das condicoces clinicas sendo perdido para seguimento apos a alta hospitalar. E realizada revisao completa da literatura dos 46 casos com envolvimento gastrico 11 dos quais acometendo somente o estomago. Os autores concluem que o conhecimento dos aspectos clinicos e cirurgicos da localizacao gastrica da doenca de Crohn e muito importante para diagnostico preciso e um tratamento compativel com a fisiopatologia da doenca

Niemann-Pick disease in adult: report of a case surgically treated.

Os autores relatam o caso de um homem de 63 anos de idade com a doenca de Niemann-Pick na forma adulta. Os dados pre operatorios eram sugestivos de doenca de Gaucher. As indicacoes cirurgicas foram a presenca de hiperesplenismo e aumento abdominal. Foi realizada esplenectomia,biopsias hepatica e de arco costal e o estudo histologico revelou doenca de Niemann -Pick. O paciente evoluiu com empiema de longa duracao. Sao feitos comentarios sobre a natureza da doenca, a raridade da forma adulta e suas manifestacoes clinicas