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Objective To investigate clinical characteristics and medium-term prognosis of the advanced elderly patients with mild ischemic stroke,and to evaluate the risk factors for poor clinical outcome.Methods The 574 elderly patients with mild acute ischemic stroke admitted in neurology department of our hospital were retrospectively studied from January 2016 to December 2017.All cases were divided into the advanced elderly group(n=276,≥80 years old)and elderly patient group(n=298,60-79 years old).Clinical characteristics were analyzed.After 12-month follow-up,the mid-term prognosis and risk factors for poor clinical outcome(mRS≥ 3)were analyzed in the two groups.Results Compared with the elderly patients,the advanced elderly patients were more often complicated with history of atrial fibrillation,diabetes and stroke(P ＜0.05).The scores of National Institute of Health stroke scale(NIHSS)and Modified Rankin Scale(mRS)were higher in the advanced elderly patients than in the elderly patients(1.37± 1.03 vs.0.94 ±0.43,2.79± 1.27 vs.1.92 ± 0.66,P＜0.001).The proportion of patients receiving anticoagulation treatment were lower in the advanced elderly patients than in the elderly patients,with no significant difference(P ＞0.05).After an average follow-up of(11.3 ± 1.5) months,the proportions of poor clinical outcome and mortality were higher in the advanced elderly patients than in the elderly patients(63.4％ or 175/276 vs.48.0％ or 143/298,25.7％ or 71/276 vs.16.1％ or 48/298,P＜0.05).Cox proportional hazard model analysis showed that age,baseline NIHSS score and mRS score,diabetes and stroke history were the risk factors for poor clinical outcome in elderly patients with mild ischemic stroke(all P＜0.05).Conclusions The advanced elderly patients with mild ischemic stroke have a severe clinical condition,higher rates of atrial fibrillation,diabetes and stroke history,and poor mid-term prognosis.Age,baseline scores of NIHSS and mRS,diabetes and stroke history are the risk factors for poor clinical outcome in elderly patients with mild ischemic stroke.
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Objective To investigate the influence of ginsenoside Rgl on the proliferation of neural stem cells in adult rats with fo- cal cerebral ischemia,and to explore the possible mechanism of ginsenoside Rg1 in brain protection and anti-aging action.Methods The animal model of left middle cerebral artery occlusion(MCAO)was reproduced in adult male Wistar rats.The thymidine analog bromode- oxyuridine(BrdU)was administered intraperitoneally(50mg/kg,Sigma,USA)every four hours for four times before executing the ani- mals to label the proliferating cells.By the employment of immunohistochemical single staining and double-immunofluorescence technique, the number of BrdU immunoreacted nuclei in the subventricular zone(SVZ),the number of nestin positive cells in the subgranular zone (SGZ)as well as the nestin/BrdU double-labeled positive cells were counted.The effect of ginsenoside Rg1 on the immunoreactivity for BrdU,nestin and nestin/BrdU at 1d,3d,7d and 14d after focal cerebral ischemia were also observed to compare with that of controls,Re- sults The immunoreacted cells of BrdU,nestin and nestin/BrdU were seen in SVZ and SGZ in the hippocampus following focal cerebral ischemia.The number of BrdU,nestin-positive cells and the double-labeled positive cells all reached the peak on 7d and decreased on 14d after MCAO,and the expressions markedly increased after the rats were given ginsenoside Rg1,compared with the control(P
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Objective To investigate the effect and significance of Ginsenoside Rg1 on the expression of neuron specific enolase (NSE) after focal cerebral ischemia in adult rats.Methods Ginsenoside Rg1 was given intraperitoneally in the rats twice a day at dose of 20 mg/kg for 5 days. Then the models of cerebral ischemia were made by occluding middle cerebral artery using an intraluminal filament method. At 3, 24, 48 and 72 h after focal cerebral ischemia, the neurological deficit score was evaluated and immunohistochemistry technique was used to observe the expressions of NSE. The above parameters were compared to control group and sham operation group.Results Compared with control group,at all the time points the neurological deficit scores were significantly decreased in Ginsenoside Rg1 group (all P