Lipid profile and serum insulin levels in gastational diabetes

To evaluate the glucose intolerance, insulin, and lipid profile in women who developed gestational Diabetes, compared to healthy pregnancy. Observational study. One hundred pregnant women, 50 healthy as control group and 50 already diagnosed gestational diabetic women as study group were selected. Plasma fasting [FBS] and post prandial glucose [RBS], serum insulin and serum lipid profile [total lipids, cholesterol, triglycerides, HDL-cholesterol and LDL-cholesterol] of both were monitored. Mean values were compared using t-test. Mean FBS [124.76 +/- 4.22 vs. 90.06 +/- 1.20 mg/dl], mean RBS [221.38 +/- 6.68 vs. 120.32 +/- 1.97 mg/dl], insulin [32.10 +/- 0.83 vs. 17.88 +/- 0.54 micro IU/ml], mean cholesterol [216.60 +/- 5.87 vs. 166.38 +/- 3.19 mg/dl], mean triglycerides [189.36 +/- 6.76 vs. 106.28 +/- 2.85 mg/dl], LDL-cholesterol [131.08 +/- 4.73 vs. 102.48 +/- 2.18 mg/dl] and total lipids [825.24 +/- 16.92 vs. 653.96 +/- 15.40 mg/dl] were higher in GDM groups as compared to normal controls [p<0.01]. Mean HDL-cholesterol [41.24 +/- 0.65 vs. 48.34 +/- 0.66 mg/dl] showed significantly lower concentration in GDM group as compared to controls [p<0.01]. Mean insulin and lipid levels, except HDL-cholesterol, were significantly higher in gestational diabetics compared to controls

Pre-eclampsia and lipid profile

The present study was designed to evaluate the role of lipid profile alteration in the development of Pre-eclampsia. We selected 32 pregnant women, 16 healthy pregnant women [mean age 25.56 +/- 3.68] as normal and 16 already diagnosed preeclamptic women [mean age 24.65 +/- 4.25] as study group. Serum lipid profile [total lipids, cholesterol, triglycerides, HDL-cholesterol and LDL-cholesterol] of thirty two women with Pre-eclampsia [n=16], normotensive women [n=16] were monitored. The serum triglyceride concentrations increased significantly [232.18 +/- 106.41 vs. 113.12 +/- 21.3, P<0.01] while Serum HDL-cholesterol concentrations decreased significantly [39.75 +/- 11.99 vs. 51.18 +/- 06.09, P<0.01] in preeclamptic group as compared to normal pregnant women. Lipid metabolism plays a key role in the pathophysiology of Pre-eclampsia. Increased triglycerides levels along with decreased HDL-cholesterol levels and delayed triglycerides clearance and high blood pressure are associated with development of preeclampsia

Incidence and outcome of preterm-premature rupture of membranes

To know the incidence and to evaluate the outcome of cases of preterm premature rupture of membranes [PPROM]. An observational study done over a period of 1 year between 31st January 1999 to 31st January 2000. 136 cases of PPROM admitted in the antenatal ward of Obstetric and Gynecology Unit II, Punjab Medical College, Divisional Head Quarter [DHQ] Hospital, Faisalabad. Main Outcome Measures: Incidence, latency period, perinatal mortality and morbidity and maternal morbidity. Incidence of Pre-term premature rupture of membrane was 5.4%. Most of the patients were below 25 years or above 30 years of age [74%, 66% respectively]. Majority belonged to low socio-economic group. Thirty-two patients had previous history of abortion or preterm delivery, seventy-eight patients delivered within first 48 hours. About 2.6% percent patients developed choriomnionitis. Eighty six percent patients delivered vaginally. Perinatal mortality was 19%. Retained placenta and abruption was seen in 0.7% cases each. PPROM is a major obstetric problem. Expectant management upto 36 weeks is a favourable option in our circumstances where neonatal intensive care units [N.I.C.U.] are not available. Prolongation of pregnancy to achieve fetal maturity can be possible by adopting strict clinical criteria thereby decreasing prematurity